... mitochondrial matrix proteinsundergo oxidative and glycoxidative modifications. Thesedamaged proteins accumulate with aging, in parallel with a large decrease in Lon protease activity.Materials and ... CML-modification in addition tocarbonylation and accumulation of these altered proteins.Besides these damaged proteins, we reported a largedecrease in the activity of a matrix enzyme, the Lonprotease, ... Changes in rat liver mitochondria with agingLon protease-like activity andNe-carboxymethyllysine accumulation in the matrixHilaire Bakala1, Evelyne Delaval1, Maud Hamelin1, Jeanne...