... also demonstrated that isoquinoline-1,3,4-trione and its derivatives protected the growth of axons and dendrites of neurons treated with Ab(25–35) and attenuated neuronal apoptosis Moreover, the ... activity, and flow cytometry analysis indicated that isoquinoline-1,3,4-trione and its derivatives attenuated the apoptosis of PC12 cells induced by Ab(25–35), but had no obvious toxicity for PC12 cells ... validated isoquinoline-1,3,4-trione and its derivatives as selective, irreversible, slow-binding, pan-caspase inhibitors This compound and its derivatives protected PC12 cells and primary cortical neuronal...