... modulators of zymogen activation in the fibrinolytic and coagulation systems Table Small-molecule zymogen modulators identified in this laboratory PHBP, plasma hyaluronan-binding protein; scu-PA, singlechain ... even in the absence of fibrin or cells PAN–K5 binding is mediated via the aminohexyl (AH) site in K5 [28,29] (Fig 3) Unlike lysine-binding sites in K1, K2 and K4 of plasminogen, the AH site can bind ... lysine-binding sites in K1 and K4 may be involved in this propagation process Thus, plasminogen binding is essential for the fibrinolytic process The kringle ligands, however, inhibit plasminogen...