Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
Stability and in vivo evaluation of pullulan acetate as a drug nanocarrier
... 300070, PR China Abstract To develop pullulan acetate nanoparticles (PANs) as a drug nanocarrier, pullulan acetate (PA) was synthesized and characterized. Its acetylation degree determined by the ... buered formalin, embedded in paraf- n, sectioned, and stained with hematoxylin and eosin (H&E). In vivo pharmacokinetics and bioavailability In vivo pharmacokinetic study was conducted ... by DAS 1.0 (Anhui, China) program. Bioavailability (BA) is a measurement of the rate and extent of a therapeutically active drug that reaches the systemic circulation and is available at the...
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Báo cáo khoa học: Insertion of the plant photosystem I subunit G into the thylakoid membrane In vitro and in vivo studies of wild-type and tagged versions of the protein doc
... amplification with primers 5¢-CACCACCACCACCACCACGAAGCTGGAGATGATCGTGCT-3¢(His-tag underlined) or 5¢-TGGAGCCACCCGCAGTTCGAAAAAGAAGCTGGAGATGATCGTGCT-3¢ (Strep-tagunderlined) and 5¢-GCGGCATGCTCATCCAAAGAAGCTTGGGTCG-3¢. ... 5¢-GCGGAGCTCATGGCCACAAGCGCATCAGC-3¢ and 5¢-GTGGTGGTGGTGGTGGTGGAAATGGGTTTTTCCGTTCTGC-3¢ (His-tag under-lined) or 5¢-TGGAGCCACCCGCAGTTCGAAAAAGAAGCTGGAGATGATCGTGCT-3¢ (Strep-tag underlined),then a secondary amplification ... designed as follows: PSAG with a C-terminalhexa-histidine tag (PSI-G-HisTerm), 5¢-GCGGAGCTCATGGCCACAAGCGCATCAGC-3¢ and 5¢-GCGGCATGCTCAGTGGTGGTGGTGGTGGTGTCCAAAGAAGCTTGGGTCGTAT-3¢ (His-tag underlined);...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc
... progression of neuronal development, as well as for cancer diagnos-tics and therapeutic application in human medicine.ConclusionRecently, the increased interest in miRNAs, and con-cerns that miRNAs are ... regu-latory networks during developmental stages and thechanges of these networks in disease and after applica-tion of a variety of therapeutic strategies. Critically,the noninvasive imaging approach ... miRNA in vivo as well as for monitoring the therapeutic potential of miRNAs in cancer.Bioimaging of microRNA biogenesisThe molecular mechanisms involved in miRNA gener-ation are complex, and at...
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Tài liệu Báo cáo khoa học: Compartmentalization and in vivo insulin-induced translocation of the insulin-signaling inhibitor Grb14 in rat liver pptx
... family of adaptor proteins, which lack intrinsic enzymaticactivity and share a common multidomain structure.These adaptors bind to several receptor tyrosine kinases and signaling proteins, and ... EEA1 (endosomal marker), Na+⁄ K+-ATPase (plasma membrane marker) and caln-exin (ER marker) as indicated. Top: representative immunoblots in control ()ins) and insulin-injected (+ins, 5 min ... protein kinase Cf, enhances the serine phos-phorylation of Grb14 and its inhibitory effect on IRkinase and insulin signaling [10]. The interaction of Grb14 with PDK-1, an upstream kinase that activatesAkt...
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Tài liệu Aesthetic preferences and the attribution of meaning: Environmental categorization processes in the evaluation of urban scenes ppt
... evaluaran tanto sus propiedades restauradoras—en te´rminos de la ART—como el gradoen que exhibı a determinadas caracterı´sticas ambientales. Los participantes expresaron una clara preferenciaeste´tica ... therestorative capacity of a specific place in terms of the ART—(Hartig, Korpela, Evans, & Ga¨rling,1997) as well as analysing the role that this capacitymay play in the selection of ‘‘favourite’’ ... area. The‘‘industrial areas’’ category is one that appeared in the responses to the most unattractive areas, a quality that was not evaluated in the first study. In any case, the categories that...
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Tài liệu Báo cáo Y học: Identification and characterization of the Escherichia coli stress protein UP12, a putative in vivo substrate of GroEL pptx
... during exponential growth; itstarts to accumulate at the early stationary phase, and itssteady-state level increases further during the late stationaryphase. As a result of this accumulation, ... conditions at the stationary phase and as a result of starvation. E. coli MC4100 was grownat 37 °C in Luria–Bertani or minimal media and the samples were withdrawn at 30-min intervals. The cell ... pKD46. Transformants were incubated 1 hat 37 °C and overnight at room temperature in SOCmedium and then plated on Luria–Bertani agar platescontaining kanamycin. Kanamycin resistant (KmR)trans-formants...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... Examination The mental status evaluation involves observing patients and asking questions to gather information about a patient’s behavior and appearance, ambulation and move-ment, mood and ... increasingly PET in the Evaluation of Alzheimer’s Disease and Related Disorders14 L.M. Ercoli and G.W. Smalldisparate items are alike (e.g., ask how a table and a chair are alike). Abstract ... educational attainment and performance and occupational history provides additional information about a patient’s pre -evaluation level of adjustment and intellectual, occupational, and social...
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Báo cáo khoa học: Two types of replication protein A in seed plants Characterization of their functions in vitro and in vivo ppt
... F1 (ATGGAGAACTCAGTGACCCAAGATGGTAT) and 70b R1 (AGAATTCTGAGGTTGAAGAAGCTAGTAA) primers, and 70b F2 (TACTATCAGCAGAAGCAATGTGGTGATA) and 70b R2(TTACTGAGATGTCTTGTTCTTGGAAATGT) primersfor atrpa70b. ... (AtRPA7 0a and AtRPA70b, respectively) and because many T-DNA insertion mutants of A. thali-ana are already available [26]. We were able to obtainone T-DNA insertion line each for AtRPA7 0a and AtRPA70b ... RNAimutants of A. thaliana homologs of OsRPA7 0a and OsRPA70b (AtRPA7 0a and AtRPA70b) A. thaliana was used for genetic analysis of the functions of OsRPA7 0a and OsRPA70b because it has closely rela-ted...
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Báo cáo khoa học: In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis pot
... Medicina y Farmacia., Universidad de Valencia, Valencia, SpainSeveral clinical trials have revealed that individuals who weregiven b)carotene and vitamin A did not have a reduced risk of cancer ... supple-mented rats by the technique of differential display. As expression of c-H-Ras was found to be lower and that of p537was higher in chronic vitamin A deficiency and c-H-Ras and p53 play an inverse ... mitochondria in rats that can be reversed byvitamin A supplementation [13]. However, the addition of retinol and retinal to cultures of HL-60 cells causes cellularDNA cleavage and an increased formation...
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