... production of interferon-γ, which has been shown during the past several years to be a key effector cytokine in the host response against tuberculosis Th2 cells primarily secrete the cytokines interleukin-4, ... Respiratory Research Vol No Schluger whole cascade of inflammatory events On the other hand, in many infectious syndromes relatively avirulent organisms cause disease mainly by forcing the host to ... phenotype, similar to a Th1 phenotype, is the predominant type of CD8+ cell; in addition, they are cytotoxic T cells and probably play a significant role in true protective immunity of the type...