Development and application of mass spectrometry based proteomics technologies to decipher ku70 functions
Development and application of mass spectrometry based proteomics technologies to decipher ku70 functions
... describes development and application of mass spectrometry based proteomics technologies to decipher Ku70 biological functions We first improve the proteomics sample preparation method in order to enhance ... Silver staining of different amount of BSA picomol, 500 femtomol, 100 femtomol, 50 femtomol, 10 femtomol, femtomol to femtomol BSA (From left to right)were loaded and run by SDS-PAGE and then stained ... Complexity in Eluate Submitting to Mass Spectrometry 62 3.3.6 Identification of Ku70 Complex by Mass Spectrometry 64 3.3.7 Validation of Search Result of Mass Spectrometry 67 3.3.8 Poly...
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the development and application of an antibody based biosensor
... spectrum of BT5AA 56 Synthesis and mass spectrum of 2TAA 58 Synthesis and mass spectrum of 3TAA 59 Synthesis and mass spectrum of 5M2TAA 60 Synthesis and mass spectrum of ... from the ancient remains of marine plant and animal life under extreme heat and pressure in an anaerobic environment Depending on the composition of the organic material, varying proportions of ... Schematic of a generalized biosensor The bioreceptor and the transducer are linked such that the transducer quantifies the biorecognition event occurring between the sample and the bioreceptor The...
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Development and application of a web based kanban system
... for a manufacturing company that aims to improve and enhance their manufacturing system and operations The major advantages of a Web- based Kanban system is the availability of visible and real-time ... withdrawal Kanban signal and place it in ‘on-hold’ status on Web- based Kanban screen [2] The withdrawal Kanban signal from Kanban screen will be translated to a production Kanban signal on Kanban ... common kanban Huang and Kusiak (1996) have further grouped the different types of kanban together into primary kanban, supply kanban, procurement kanban, subcontract kanban and auxiliary kanban Table...
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Báo cáo sinh học: "Metabolite-based clustering and visualization of mass spectrometry data using one-dimensional self-organizing map" ppt
... Figure Visualization of one-dimensional self-organizing map after clustering Visualization of one-dimensional self-organizing map after clustering 1D-SOM matrix after metabolite-based clustering ... metabolite-based clustering and visualization of large sets of metabolic marker candidates based on self-organizing maps (SOMs) Unlike applications of the classical two-dimensional SOMs, we are proposing one-dimensional ... condition The identification of metabolites was verified by exact mass measurement and coelution with authentic standards Data processing The raw mass spectrometry data of all samples were processed...
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Báo cáo y học: "Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery" docx
... article as: Kooren et al.: Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery Clinical Proteomics ... DeSouza LV, Matta A, Tripathi SC, Ghanny S, DattaGupta S, Thakar A, Chauhan SS, Siu KWM: iTRAQMultidimensional Liquid Chromatography and Tandem Mass Spectrometry-Based Identification of Potential Biomarkers ... Collectively our results demonstrate the great potential of our exudate collection method for oral cancer biomarker discovery and clinical diagnostics Methods Patient information Exudates and brush...
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Báo cáo hóa học: " Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood" pptx
... biomarkers, and they participated in the data analyses AAH developed the customized Spotfire tool used for data analyses and reviewed statistical analyses YG participated in the assessment and ... assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood Journal of Translational Medicine 2010, 8:51 Page 13 of 13 ... this basic approach (ex vivo stimulation of whole blood) to develop pharmacodynamic biomarker assays for a candidate therapeutic antibody, Ab-01 Ab-01, a human antibody generated by phage display,...
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báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... designed and managed the valuation survey, analysed and reported on the valuation data and contributed to the writing of the manuscript All authors read and approved the final manuscript Acknowledgements ... state Validation of the preference based CAMPHOR scale A majority (87.8%) of the 91 participants in the CAMPHOR validation survey were in New York Heart Association (NYHA) classes II and III The ... group for use in the UK valuation of the EQ-5D For health states that a respondent regards as better than being dead, they are asked to imagine two scenarios: 1) live in a state for 10 years (t) and...
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báo cáo hóa học: " Development and evaluation of a computer-based medical work assessment programme" pdf
... CA1 CA MA1, SA MA, SA1 MA, SA MA, SA MA, SA Event +CA2 +SA +MA2 + SA2 +CA -SA -MA Result CA1 stop CA2 start CA → MA SA start MA1 stop MA2 start SA1 stop SA2 start MA stop SA stop CA start SA ... data from each case is transferred to a PC and evaluated statistically and graphically: the number of individual occurrences of each task, mean duration of each occurrence of each task, the total ... "Stop" has to be hit At this moment all events of the observation are automatically saved in a tab-delimited file Application of the job task analysis tool The time recording software translates...
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báo cáo khoa học: "Applying mass spectrometry based proteomic technology to advance the understanding of multiple myeloma" ppt
... receptor in MM Importantly their mass Page of 11 spectrometry approach demonstrated the potential for pharmacodynamic monitoring The future of mass spectrometry in biomarker discovery The use of mass ... this article as: Micallef et al., Applying mass spectrometry based proteomic technology to advance the understanding of multiple myeloma Journal of Hematology & Oncology 2010, 3:13 ... all cases of MM arise from MGUS [55] On the other hand, the majority of MGUS cases will not develop into MM Although the status of M-protein may offer insight into the development of MM, it is...
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Báo cáo y học: "Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon" ppsx
... (and Lys) tend to be over- High density IJISS DNA arrays have been developed for global analysis of Streptomyces gene expression and transcription factor binding The HspR regulatory system of S ... against the test arrays and the probe performance was scored using the following equations Firstly the Cy3 and Cy5 background-subtracted signals, designated 'g' and 'r', respectively, obtained by feature ... chaperone and protease production It is envisaged that these arrays will find widespread use in systems level analysis of Streptomyces coelicolor biology Materials and methods Streptomyces strains and...
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synthesis and application of functionalized diene-based polymers(fileminimizer)
... substitution of poly(4-fluoro-2,5benzophenone) with various nucleophiles .7 1-4 Synthesis of functionalized polythiophenes 1-5 Synthesis of functionalized PLA and PCL 1-6 Synthesis ... 1-6 Synthesis of functional polyesters In the following chapters, the functionalized monomer approach is used to prepare functionalized diene-based materials Synthesis of a wide variety of functionalized ... Scheme 1-4 Synthesis of functionalized polythiophenes15 Nadeau et al reported the synthesis of functionalized poly(lactic acid)s (PLA) and poly(caprolactone)s (PCL) for biomedical applications...
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DEVELOPMENT AND APPLICATION OF NEW APPROACHES FOR STUDIES OF INFLUENZA INDUCED INFLAMMATION AND DNA DAMAGE
... of influenza A (H1N1) virus infection to explore the impact of influenza infection and inflammation on DNA damage and DNA damage responses By studying chromatin phosphorylation as a measure of DNA ... of DNA damage, we show that the level of DNA damage increases following influenza infection, and we provide data that supports a role for replication fork breakdown as a driver of DNA strand breaks ... Together, these studies raise the possibility that DNA damage and DNA repair modulate the severity of influenza -induced cytotoxicity, thereby affecting tissue damage and regeneration, and ultimately...
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Development and application of a high throughput assay for discovery of starch hydrolase inhibitors
... αglucosidase and α-amylase can significantly reduce the post-prandial increase in blood glucose after a meal, with starch as the major calorie intake The apparent advantage of the starch hydrolase inhibitors ... linear range of gelatinized starch Table Accuracy and precision of the high- throughput method Table IC50 and acarbose equivalence of inhibitors obtained by starch hydrolases Table Estimation of ... of starch involves saliva α-amylase, pancreatic αamylase, and the small intestinal brush border α-glucosidase, that is, maltaseamyloglucosidase and sucrase-isomaltase [19, 67] Determination of...
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Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
... develop and apply computational methods and tools for ADR and toxicity prediction The methods developed in this work are potentially useful for development and application of QSAR models as well ... complex, time consuming and resource intensive Toxicity is one of the primary reasons for the failure of drug candidates in later stages of drug development Moreover, adverse drug reaction (ADR) during ... drug development and safety assessment 1.2 QSAR studies for ADR and toxicity prediction To deliver promising drug candidates to reach the late stage of drug development with a higher chance of...
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Từ khóa: use of colloidal silica beads for the isolation of cell surface proteins for mass spectrometry based proteomicsdevelopment and application of genomic models for large crop plant genomesdevelopment and application of new systemsapplication of a gis based statistical method to assess spatio temporal changes in breast cancer clustering in the northeastern united statesresearch development and demonstration of indigenously developed solar dish technologiestargeted mass spectrometry based metabolomic profiling through multiple reaction monitoring of liver and other biological matricesapplication of mass balances to the processing of raw plant and animal materialsapplications of mass spectrometry to analyze structure and bioactivity of chitooligosaccharidesanalysis of simple carbohydrates by capillary electrophoresis and capillary electrophoresis mass spectrometrycapillary electrophoresis and capillary electrophoresis mass spectrometry for structural analysis of n glycans derived from glycoproteinsextended release oral dosage forms development evaluation and application of in vitro in vivo correlations guidance 1997structures properties and application of nanostructured shape memory tini based alloyscoupling the administration of stable isotopes with mass spectrometry based analysesgeneration and application of virtual landscape models for location based servicesthese competences are gradually expressed through the complicated interaction between visible and invisible resources by time and are usually based on the development and exchange of information and knowledge via company s human resourcesBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật