... octamer and the factors binding to it in LPS-induced gene expression Although involvement of octamer-binding factor- 1 (Oct-1), another octamer-binding protein, cannot be excluded in the LPSinduced expression ... expression of iNOS and G-CSF protein and mRNA were evaluated in macrophages, and the involvement of Oct-2 in LPS ⁄ mTOR-induced iNOS and G-CSF expression was investigated further Results Rapamycin inhibits ... and be inhibited by the mTOR inhibitor, rapamycin In addition, Oct-2 is involved in the expression of LPS -inducible genes that contain octamer in their promoters [24,25] Thus, rapamycin may inhibit...