Role of the neuropeptide substance p in burn induced distant organ damage

... Neurokinin-1 receptor PMN Polymorphonuclear PPT-A Preprotachykinin-A PGE2 Prostaglandin E2 RT-PCR Reverse transcription-polymerase chain reaction SP Substance P TNF-α Tumor necrosis factor- α TRPV1 ... understanding the role of mediators that contribute to the pathophysiology of burn- induced ALI However, the role of SP in inducing inflammation in the lungs after burn injury is not known Therefore, ... 2008 The neuropeptide Substance P is a key mediator in the development of systemic inflammatory response syndrome and lung damage following burn injury 1st International Singapore Symposium in...

Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx

... activation of the glutaminase reaction and CTP synthesis was compared (Fig 5) In the absence of GTP, the rate of glutamine hydrolysis was signicantly higher than the rate of CTP synthesis so that the reactions ... (min) Fig Isothermal titration calorimetry of the glutaminase activity of L lactis CTP synthase (A) Enthalpogram showing the recording of steady-state rates for the hydrolysis of glutamine at increasing ... of the glutaminase reaction of CTP synthase from L lactis in order to distinguish between the effects of GTP on the glutaminase reaction and the CTP synthesis reaction The results from this work...

Báo cáo khoa học: Role of the C-terminal extension in a bacterial tyrosinase Michael Fairhead and Linda Thony-Meyer doc

... core tyrosinase domain [1] One proposed function of the C-terminal extension in plant and fungal polyphenol oxidases is a role in membrane binding, making them similar to the mammalian tyrosinases, ... three domains: a twin arginine translocase (TAT) signal peptide, a core domain containing the two copper-binding motifs and a C-terminal extension (Fig 1B) The presence of a predicted TAT signal peptide ... pro -tyrosinase, trypsinized pro -tyrosinase or recombinant core tyrosinase signiﬁcantly increases the overall stability of the protein It was also apparent that the C-terminal extension of pro -tyrosinase reduces...

Báo cáo khoa học: The role of the Fe-S cluster in the sensory domain of nitrogenase transcriptional activator VnfA from Azotobacter vinelandii potx

... upstream of the GAF domain are the potential ligands of the Fe-S cluster Consequently, the binding of the ATP analog and the subsequent rearrangement of the interdomain interaction affects the electronic ... with the reconstitution of Fe-S clusters in aerobically puriﬁed apo -VnfA support the presence of [Fe3S4]+ in VnfA To obtain further evidence demonstrating the involvement of the Fe-S cluster in in ... Strep -VnfA indicate that the N-terminal cysteine residues are plausible candidates for the ligands of the Fe-S cluster Thus, the locus of the Fe-S cluster should be in the N-terminal GAF domain...

Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx

... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the ... better stability than the other form (Fig 4C) The DG of stability is on an average 20% greater in the case of the holoprotein as compared to the apoprotein Similarly, the Cm of the holo form always...

Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt

... additional N -domain, homologous to the N-domains of ClpA or ClpB, and a linker domain homologous to, but half the size of, the linker domain of ClpB [19] The N-terminal region contains two 32-amino acid ... tuberculosis ClpC1 has an inherent ATPase activity and also functions like a chaperone in vitro Furthermore, we investigated the role of the N-terminal domain of M tuberculosis ClpC1 in its structure and ... and the intervening sequence between repeats I and II forms its N-terminus (Fig 2B) ClpC1D2 contains the N-terminal repeat I and the intervening sequence between repeats I and II deleted, and the...

THE ROLE OF THE FINANCIAL SERVICES SECTOR IN EXPANDING ECONOMIC OPPORTUNITY potx

... to being part of the dynamic growth and development occurring in this field THE ROLE OF THE FINANCIAL SERVICES SECTOR in Expanding Economic Opportunity I The Role of the Financial Services Sector ... Role of the Automotive Sector in Expanding Economic Opportunity Forthcoming The Role of the Extractive Sector in Expanding Economic Opportunity Holly Wise and Sokol Shtylla The Role of the Financial ... within the financial sector and beyond THE ROLE OF THE FINANCIAL SERVICES SECTOR in Expanding Economic Opportunity 19 I Case Profiles 5.1 ICICI LOMBARD: WEATHER-INDEXED CROP INSURANCE FOR RAIN-FED...

Báo cáo y học: "The role of the purinergic P2X7 receptor in inflammation" pot

... variety of inflammatory brain insults, underpinning the view that P2X7R antagonists may be of therapeutic use for the treatment of several disorders including stroke, traumatic brain injury (TBI), ... in animal models of disease has yet to be published The role of the P2X7R in inflammatory cell function Since nucleotides (such as ATP) are normally retained within the cytoplasm of a cell, their ... pro-inflammatory cytokine that is produced in response to injury, exerting a number of important roles in the immune system and during inflammatory responses It is of particular interest in neuropathology...

Báo cáo y học: " Role of the tachykinin NK1 receptor in a murine model of cigarette smoke-induced pulmonary inflammation" docx

... smoke-induced airway neutrophilia was attenuated by a dual tachykinin NK1/ NK2 receptor antagonist in guinea pigs [22] The purpose of this study was to characterize the precise role of the tachykinin ... whereby a role for the tachykinin NK1 receptor in macrophage and DCs accumulation was demonstrated The impaired accumulation of these cell types seems, at least partially, mediated by the attenuated ... of mice [49] To conclude, the tachykinin NK1 receptor is involved in the accumulation of inflammatory cells in the airways during the inflammatory response to CS in a mouse model of COPD As inflammation...

Báo cáo y học: " Angiotensin-converting enzyme 2 autoantibodies: further evidence for a role of the renin– angiotensin system in inflammation" potx

... aldosterone antagonists which may increase basal ACE2 expression potentially contributing to the protective mechanisms of these therapies There is increasing evidence for the interplay of the renin angiotensin ... mechanism to alter the balance of the renin angiotensin system to favor the ACE2– Ang-(1–7)–AT7 receptor axis and promote the antiﬁbrotic and anti -in ammatory actions of the heptapeptide, as well ... potential importance in our understanding of the role of circulating and tissue sources of ACE2, particularly in various disease states Increased circulating levels of ACE2 may reﬂect a compensatory...

Báo cáo y học: " Role of the Fas/FasL Pathway in HIV or SIV Disease" ppsx

... preserved by the treatment Another indication of the importance for indirect cell killing comes from studies of "naturally-infected" macaques i.e., sooty mangabeys infected with SIVsmm that maintain ... sparing the fraction of infected cells Such a process will tend to increase the proportion of infected cells and diminish the proportion of uninfected cells in a tissue heavily burdened by SIV or ... pathogenesis of HIV/ AIDS http://www.retrovirology.com/content/6/1/91 Significance of indirect cell killing for HIV vaccine/ therapeutics design Knowing the role for uninfected bystander cell killing in...

Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf

... diversity (Shannon's Figure intensity and distribution of positively selected sites in the C2, V3 and C3 regions along the course of HIV-2 infection Frequency, Frequency, intensity and distribution of ... evolution of the HIV-2 env gene In the present study we analyze, for the first time, the molecular evolution of the env C2V 3C3 regions in chronically HIV-2 infected patients over a two to four year period ... along the course of infection Figure Frequency and distribution of potential N-glycosylation sites in the C2, V3 and C3 regions along the course of infection The frequency and distribution of potential...

Báo cáo y học: "Clinical review: The role of the intensive care physician in mass casualty incidents: planning, organisation, and leadership" pot

... up in the operating theatre recovery area This work was done mainly by the critical care outreach team (CCOT), but during the event all of the intensive care patients were accommodated within the ... casualties The difficulty in planning was the uncertainty of when the flow of seriously injured casualties would stop It was noted in the Madrid bombings of 2004 that the hospitals closest to the incidents ... checking of staff identity) is maintained? Who is the lead intensivist and who is the senior nurse? Are their roles clearly defined? What is the absolute limit in terms of increasing bed capacity?...

Báo cáo y học: " The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury" ppsx

... Kim HY, Jung KH, Kang EH, Lee SY, Suh IB, Shin C, Shim JJ, In KH, Yoo SH, Kang KH: Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury Crit ... be clinically relevant, is frequently necessary to induce appropriate lung injury Competing interests The authors declare that they have no competing interests References Kim JH, Suk MH, Yoon ... ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: an in vivo model using clinical relevant ventilation settings Anesthesiology...

Investigation of the role of the ubiquitin proteasome pathway in dengue virus life cycle 1

... 11 1 Figure 4 .1: Schematic diagram of findings 11 4 xii Chapter 1: Introduction 1. 1 Dengue 1. 1 .1 Dengue – a disease of global significance Dengue has emerged ... DEN Figure 1- 2 Distribution of DENVs 1- 4 in (A) 19 70 and (B) 2 011 Compared to the 19 70s, the increased incidence and spread of all four dengue serotypes observed in 2 011 indicates the urgent ... reaction (qRT-PCR) 14 1. 1.4.5 NS1 antigen detection 15 1. 2 Role of host and viral factors in dengue pathogenesis 17 1. 2 .1 Host factors 17 1. 2 .1. 1 Epidemiological evidence...

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