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Excluded volume effects in molecular biology and extracellular matrix biochemistry biophysical considerations and molecular modeling

Excluded volume effects in molecular biology and extracellular matrix biochemistry  biophysical considerations and molecular modeling

Excluded volume effects in molecular biology and extracellular matrix biochemistry biophysical considerations and molecular modeling

... Crowding influences Intra-cellular Trafficking 6.4 Macromolecular Crowding on Protein-folding and Stability 6.5 Macromolecular Crowding Effects on Protein-Aggregation 6.6 Macromolecular Crowding Effects ... frequently increasing the binding strength by at least an order of magnitude (Wilf & Minton, 1981) 6.4 Macromolecular Crowding on Protein-folding and Stability Crowding influences protein stability ... Acid Single Strands 83 10.6.2 Mixed MMC greatly enhances DNA-thermal Stabilizing Effects 84 10.6.3 A Combined in vitro -in silico Approach 86 10.6.4 Crowding Effects by Confinement 87 11 Macromolecular...
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Báo cáo y học: "Biology of recently discovered cytokines: Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthrits" pdf

... H, Andoh A, Makino J, Shimada M, Tasaki K, Araki Y, Bamba S, Hata K, Fujiyama Y, Bamba T: Interleukin-17 stimulates chemokine (interleukin-8 and monocyte chemoattractant protein-1) secretion in ... Finally, data from IL-1 7–/ and IL-17R– /– mice indicate that this cytokine is also involved in a variety of other T cell dependent events For example, delayed type hypersensitivity and contact hypersensitivity ... CW, de Waal Malefyt R, Wierenga EA, γ Bos JD: Interleukin-17 and interferon-γ synergize in the enhancement of proinflammatory cytokine production by human keratinocytes J Invest Dermatol 1998,...
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Báo cáo y học: "The CRIT framework for identifying cross patterns in systems biology and application to chemogenomics" ppt

... phosphorylation in yeast Nature 2005, 438: 679-684 23 Yip KY, Yu H, Kim PM, Schultz M, Gerstein M: The tYNA platform for comparative interactomics: a web tool for managing, comparing and mining multiple ... proteins and in DNA binding for AR and hydrophilicity-sensitive proteins In addition, charge-sensitive proteins showed an enrichment in transferase activity and MlogP in transcriptional regulator ... We used two types of networks: protein-protein interactions and gene regulatory [21] (genetic interaction and phosphorylome [22] had too few nodes to determine significance) All topological statistics...
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Báo cáo y học: "Gene-dosage effects in Down syndrome and trisomic mouse models" pot

... Approximately185 and/ or tissues, and that background and stochastic or transient effects may be confounding factors Large-scale studies of gene-dosage effects in Down- syndrome fetuses and trisomic ... They used RNA from four normal and four Down- syndrome cerebrums and from four normal and four Down- syndrome- derived astrocyte cell lines cultured from cerebral cortex Samples were analyzed individually ... segmental trisomy mouse models for Down syndrome has focused on this region Currently, the best mouse models of Down syndrome are the Ts65Dn mouse (reviewed in [11,12]) and the Ts1Cje mouse [13] Ts65Dn...
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Mechanical characterization of biopolymer and the effects of mechanical properties of extracellular matrix on cell behaviours

Mechanical characterization of biopolymer and the effects of mechanical properties of extracellular matrix on cell behaviours

... MECHANICAL CHARACTERIZATION OF BIOPOLYMER AND THE EFFECTS OF MECHANICAL PROPERTIES OF EXTRACELLULAR MATRIX ON CELL BEHAVIORS WONG LONG HUI (B.Eng.(Hons.), NTU) A THESIS SUBMITTED FOR THE ... in cell and extracellular matrix interactions The first part of the thesis involved the use of conventional macrorheological technique to uncover the rich mechanical properties of collagen, the ... the cancer cells and the physical microenvironment, through cell- cell and cell- ECM interactions, determines the progression of the invasion process, as shown in Figure 1.4 [39] The interactions...
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Electrical conductivity switching behavior and memory effects in electroactive polymers and nanocomposites

Electrical conductivity switching behavior and memory effects in electroactive polymers and nanocomposites

... linear (Ohmic) behavior of the current response in the polymer thin film, resulting in electrical conductivity switching behavior and memory effect in the sandwich structure The individual memory ... insulator, bistable electrical conductivity switching (WORM memory and flash memory effects) , and conductor behaviors, when the CNT content in the composite film is increased from to 3% The conductivity ... SUMMARY Organic and polymeric materials can exhibit electric-field-induced electrical conductivity switching behavior and resistor-type electronic memory effects The field-induced electrical bistability,...
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Báo cáo y học: " Heterogeneity in multistage carcinogenesis and mixture modeling" ppsx

... use mixture models to allow for variability among individuals This allows us to introduce heterogeneity in a biologically meaningful way In the next section, we describe the multistage carcinogenesis ... threshold value may abrupt changes in the system occur Since we consider a late end-point, namely cancer, in a very complicated system, it is not surprising that we obtain in Section mixture models ... model and introduce an extension by mixture Then we will give a series of identifiability results for both the multistage model and some mixture models Finally, we apply the model to human incidence...
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Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot

Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot

... be involved in recognition of the methylated Lys4 amino group Multidomain organization of LSD1 and its enzymatic activity in the chromatin context Genes coding for LSD1 ⁄ K -demethylase proteins ... protein–protein and DNA–protein interactions [36] The name of this domain derives from its original identification in the proteins SWI3, Rsc8 and Moira, which are ATP-dependent chromatin remodeling ... during cell division, and LSD1 was shown to be essential in resetting this memory in the germline in order to ensure pluripotency [21] In parallel, a role for LSD1 in gene activation was originally...
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