... ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF7 in vitro Journal of Experimental ... recepter alpha (ER a ), matrix metalloproteinase 9(MMP-9), cyclinD1, and on cancer cells invasion, proliferation and cell cycle cell in two cell lines were investigated Page of 11 Construction of ... menbrane components One member of this family, MMP-9 was up-regulation in invasive cancers, including breast cancer After silencing of MTA1 gene, we investigated the alteration of tumor cells invasiveness...