of bioactive components in kefir mother culture that inhibit proliferation of cultured mcf 7 human breast cancer cells
Atomic force microscopy study of emodin treated MCF 7 human breast cancer cells
Ngày tải lên :
30/09/2015, 14:23
... The effects of emodin on the filamentous structures of MCF 7 cells were examined by acquiring AFM images from three sets of samples: MCF 7 cells, MCF 7 cells pre‐ treated with 20µM emodin, and MCF 7 cells pre‐treated with DMSO. About 5 to 10 ... The effects of emodin on the elasticity of MCF 7 cells were examined by collecting force curves on three sets of samples: MCF 7 cells, MCF 7 cells pre‐treated with 20µM emodin, and MCF 7 cells pre‐treated with DMSO. Twenty well spread cells ... signal collected in AFM indentation on living MCF- 7 cells 35 vii Figure 13 Force versus indentation curves for AFM indentation on living MCF- 7 cells 37 Figure 14 The effects of emodin on the micromechanical...
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báo cáo khoa học: " Salivary a-amylase exhibits antiproliferative effects in primary cell cultures of rat mammary epithelial cells and human breast cancer cells" docx
Ngày tải lên :
10/08/2014, 10:21
... precursor cells [34] but may also appear in cultured epithelial cells [35] To distinguish between different populations of cells, double labeling of cellular cytokeratin and vimentin was performed Cells ... 29.81 ± 2 .78 n.s *H2O vs 50 U/ml n.s F344, P1 F344, P2 Lewis, P2 Number of cells/ well Cell counts Number of cells/ well Number of cells/ well Control (H2O) 17, 250 ± 1, 377 4,500 ± 577 4,188 ± 5 67 U/ml ... seeding density of 15,000 cells/ cm2 (seeding density in some experiments 12,000-20,000 cells/ cm2), and cultured for 2-4 days (in one experiment days) prior to a-amylase treatment Finally, cells...
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Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf
Ngày tải lên :
17/03/2014, 23:20
... polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines Cancer Res 51, 371 5– 372 0 ... extensively induce cell death in the human breast cancer cell line L56Br-C1 This cell line carries a germ-line mutation (1806 C fi T) in the BRCA1 tumour Fig Propidium iodide-stained nuclei of L56Br-C1 cells ... exposure of the drug Rapid and extensive induction of cell death (within 48 h of treatment) has been observed in SK-MEL-28 cells [14], a human melanoma cell line that contains a mutated p53 gene In...
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Báo cáo khoa học: Identification of carbonic anhydrase 9 as a contributor to pingyangmycin-induced drug resistance in human tongue cancer cells ppt
Ngày tải lên :
06/03/2014, 22:21
... GTP-binding protein rab22b Minichromosome maintenance protein homolog Ribosomal L1 domain containing Hepatocellular carcinoma-associated protein HCA10 Chromosome 20 ORF 30 Splicing factor proline ... protein), c11 Polyglutamine-binding protein FK506-binding protein Phosphoserine phosphatase-like Chromosome 15 ORF 24 Coiled-coil domain-containing protein 72 Dihydropyrimidinase-like ADP-ribosylation ... protein S4, X-linked Desmuslin isoform B; desmuslin isoform A Histone cluster MYST histone acetyltransferase (monocytic leukemia) Guanine nucleotide-binding protein (G protein), c11 Polyglutamine-binding...
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Báo cáo khoa học: Ionizing radiation utilizes c-Jun N-terminal kinase for amplification of mitochondrial apoptotic cell death in human cervical cancer cells pptx
Ngày tải lên :
07/03/2014, 05:20
... nasopharyngeal carcinoma cells [13] Further studies have shown that phosphorylation of Bcl-2 on residues of in its loop domain, including Ser70 and Ser 87, is critically involved in the apoptotic ... development of molecular targets for cancer treatment Results To examine the kinetics of the apoptotic cell death induced by ionizing radiation in human cervical cancer cells, we treated HeLa cells ... changes in the expression of TNFR or DRs (Fig 1B) In addition, the protein synthesis inhibitor cyclohexamide completely inhibited radiation-induced Fas expression (Fig 1B), indicating that the...
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Báo cáo khoa học: Modulation of IMPDH2, survivin, topoisomerase I and vimentin increases sensitivity to methotrexate in HT29 human colon cancer cells docx
Ngày tải lên :
07/03/2014, 16:20
... validation of IMPDH2 HT29-R cells were incubated with increasing concentrations of chemical inhibitors of IMPDH activity, benzamide riboside, tiazofurin or mycophenolic acid, in the presence and in the ... validation of survivin Targeting of survivin was carried out by lipofecting aODN-SURV in HT29 cells This antisense oligonucleotide caused a decrease of 80% in the expression of FEBS Journal 272 (2005) ... absence of MTX It can be observed in Fig 6C that transfection with lg of pcDNA-VIM caused an increase in vimentin protein levels in HT29 cells The overexpression of vimentin sensitized the cells...
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Báo cáo hóa học: " Mass spectrometry-based analysis of therapy-related changes in serum proteome patterns of patients with early-stage breast cancer" pot
Ngày tải lên :
18/06/2014, 16:20
... based on areas of the raw spectra, averaging of technical repeats, binning of neighboring points to reduce data complexity, removal of the spectral area below baseline and normalization of the total ... identifying subgroups of patients with different patterns of changes in intensities of spectral components in time (between samples B and C) In this analysis the procedure of unsupervised clustering ... Identification of serum proteins related to adverse effects induced by docetaxel infusion from protein expression profiles of serum using SELDI ProteinChip system Anticancer Res 2005, 25:11 97- 1203 Goncalves...
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báo cáo hóa học:" The effect of peer-led education on the life quality of mastectomy patients referred to breast cancer-clinics in Shiraz, Iran 2009" pot
Ngày tải lên :
20/06/2014, 16:20
... our findings will contribute to delegating caring responsibility to these patients and facilitating the establishment of a counseling center in the breast cancer clinics Overall breast cancer ... 12 .79 ± 10.63 3. 67 ± 4.19 * Control 16 .79 ± 18. 87 17. 04 ± 19.19 17. 29 ± 19.69 001 Breast symptoms Case 18. 87 ± 18.92 18 .70 ± 18.90 17. 51 ± 19.41 Control 13.60 ± 15.28 13.94 ± 15.53 14.28 ± 15 .77 ... of Cancer Quality of Life Breast Cancer Questionnaire Acknowledgements The authors would like to thank the director of Mottahari Breast Cancer clinic in Shiraz (Dr Talei) and director of Chemotherapy...
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Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc
Ngày tải lên :
09/08/2014, 03:21
... 10.1186/1 477 -78 19-8-31 Cite this article as: Zheng et al., The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer ... Untreated SGC7901 cells; (b-f) 15 μmol/L arsenic trioxide-treated SGC7901 cells The cells were stained using DAPI staining B Untreated SGC7901 cells stained by anti-Bcl-2 N terminus antibody C SGC7901 ... at determining whether arsenic trioxide inhibits proliferation and induces apoptosis in SGC7901 human gastric cancer cells, accompanied by conformational changes of Bcl-2 and changes in total...
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Báo cáo khoa học: "Real time PCR analyses of expression of E-cadherin, alpha-, beta- and gamma-catenin in human breast cancer for predicting clinical outcome" pps
Ngày tải lên :
09/08/2014, 07:21
... relationship of E-cadherin, α-catenin, β-catenin and γ-catenin in breast tumours to Nottingham Prognostic Index (NPI) (E-cadherin p = 0.094, αcatenin p = 0.144, β-catenin p = 0. 378 , γ-catenin p = 0.131) ... beta1-integrins in invasive breast cancer J Pathol 1999, 1 87: 523-529 Dillon DA, D'Aquila T, Reynolds AB, Fearon ER, Rimm DL: The expression of p120ctn protein in breast cancer is independent of ... staining as a separate category Thus, it is possible that lobular carcinoma cases with cytoplasmic staining were included in the general category of reduced expression of E-cadherin staining...
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Báo cáo khoa học: "Cell death by the quinoxaline dioxide DCQ in human colon cancer cells is enhanced under hypoxia and is independent of p53 and p21" pdf
Ngày tải lên :
09/08/2014, 09:20
... treatments FHs74Int normal human intestinal cells were cultured in Hybri-Care medium supplemented with 30 ng/ml epidermal growth factor HCT116 (p53+/+) human colon cancer cells were maintained in RPMI ... compound that induces apoptosis in several murine and human cancer cell lines [4,5,8] This is our first attempt to understand the role of p53 and p21 in drug efficacy using colon cancer cells that ... pro-apoptotic caspase-2 protein, inhibition of the pro-survival protein PIDD-C, and increase in p-ATM expression, a major protein kinase involved in repair of DSB DCQ belongs to a group of heterocyclic compounds...
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báo cáo khoa học: " Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro" pptx
Ngày tải lên :
10/08/2014, 10:21
... expression of the maternally imprinted tumor suppressor gene ARHI in breast cancer cells Expression of ARHI is markedly down-regulated in breast cancer, and reactivation of ARHI expression in breast cancer ... target gene induction [ 27] There may be another pathway JMJD2A involved in human breast cancer It was described that JMJD2A has molecular characterization in binding both retinoblastoma protein (pRb) ... consequence [ 27] Consisting with that research, our data showed that silencing of JMJD2A could suppress the proliferation, migration and invasion of MDA-MB-231 cell line, thereby indicating that JMJD2A...
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báo cáo khoa học: "Inhibition of angiogenesis- and inflammation-inducing factors in human colon cancer cells in vitro and in ovo by free and nanoparticle-encapsulated redox dye, DCPIP" pptx
Ngày tải lên :
11/08/2014, 00:22
... Angiogenesis in Gastric Cancer Cancer Microenviron 2009 in press 14 Waugh DJ, Wilson C: The interleukin-8 pathway in cancer Clin Cancer Res 2008, 14(21): 673 5-41 15 Nishimoto N: Interleukin-6 in rheumatoid ... and pro-inflammatory factors, VEGF, COX-2, IL-6 and IL-8, in cultured human colon cancer cells; (c) DCPIP and DCPIP NPs are similarly effective in inhibiting VEGF-induced angiogenesis in ovo; ... angiogenesis in gastric cancer [13], and acquisition of chemotherapeutic resistance in androgenindependent proliferation of prostate cancer cells [14] Finally, there is extensive experimental and clinical...
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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc
Ngày tải lên :
11/08/2014, 00:23
... prognostic role of the insulin growth factor pathway members insulin-like growth factor-II and insulin-like growth factor binding protein-3 in serous effusions Hum Pathol 2009, 40:5 27- 37 17 Star A, ... Page of 14 Kim JH, Cho YH, Park YL, Sohn JH, Kim HS: Prognostic significance of insulin growth factor-I receptor and insulin growth factor binding protein-3 expression in primary breast cancer ... density J Clin Invest 2002, 110 :77 1 -78 1 25 Shukla V, Coumoul X, Vassilopoulos A, Deng CX: IGF signaling pathway as a selective target of familial breast cancer therapy Curr Mol Med 2008, 8 :72 7 -74 0 26...
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báo cáo khoa học:" The effect of peer-led education on the life quality of mastectomy patients referred to breast cancer-clinics in Shiraz, Iran 2009" pot
Ngày tải lên :
12/08/2014, 01:21
... our findings will contribute to delegating caring responsibility to these patients and facilitating the establishment of a counseling center in the breast cancer clinics Overall breast cancer ... 12 .79 ± 10.63 3. 67 ± 4.19 * Control 16 .79 ± 18. 87 17. 04 ± 19.19 17. 29 ± 19.69 001 Breast symptoms Case 18. 87 ± 18.92 18 .70 ± 18.90 17. 51 ± 19.41 Control 13.60 ± 15.28 13.94 ± 15.53 14.28 ± 15 .77 ... of Cancer Quality of Life Breast Cancer Questionnaire Acknowledgements The authors would like to thank the director of Mottahari Breast Cancer clinic in Shiraz (Dr Talei) and director of Chemotherapy...
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Evaluation of thymoquinone for cytotoxic activity against human breast cancer cell lines and tumor xenograft in nude mice
Ngày tải lên :
10/09/2015, 09:09
... production in breast cancer cells 70 Figure 3.4.2 Effect of NAC on TQ-induced cytotoxicity in breast cancer cells 72 xii Figure 3.4.3 The role of ROS in TQ-induced apoptosis 74 Figure ... signs of breast cancer include lump in breast area, change in nipple appearance, fluid leaking from the nipple and skin dimpling After detection of signs and symptoms of breast cancer, imaging ... of TQ on ROS production in breast cancer cells was not explained Therefore, we were interested in investigating the role that ROS might play in the anticancer effects of TQ The relationship of...
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Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
Ngày tải lên :
11/09/2015, 10:06
... 1.1.3 Breast cancer Incidence of breast cancer Classification of breast cancer Aetiology of breast cancer 1 1.2 1.2.1 1.2.2 1.2.3 1.2.4 1.2.5 1.2.6 HER-2/neu-positive breast cancer Definition Clinical ... XVI Chapter Introduction CHAPTER INTRODUCTION 1.1 Breast cancer 1.1.1 Incidence of breast cancer Breast cancer is the second leading cause of cancer deaths in women today after lung cancer and ... frequent cancers affecting Singapore women, 2003-20 07 Breast cancer is the top cancer type affecting the women in Singapore Data extracted from Singapore Cancer Registry, Interim Report: Trends in Cancer...
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Investigations into the effects of traditional chinese medicinal herbs used in the treatment of human breast cancer
Ngày tải lên :
15/09/2015, 17:10
... property against breast cancer We evaluated the tumor cell growth inhibitory effect of the xvii crude ethanolic extract of SN on MCF- 7, T-47D, ZR -75 and MDA-MB -231 human breast cancer cell lines The ... medicine in the treatment of disease states like breast cancer 1.4 Rationale and purpose of this study Breast carcinoma is a common cancer in women and is a leading cause of cancerrelated deaths in ... Results of cytotoxicity assays of Solanum nigrum and Scutellaria barbata in MCF- 7 human breast cancer cell lines … 82 3.5.2.2 Results of cytotoxicity assays of Solanum nigrum and in MCF- 7, ...
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ANTI CANCER EFFECTS OF THYMOQUINONE IN BREAST CANCER CELLS INVOLVEMENT OF NON HOMOLOGOUS END JOINING AND TELOMERE TELOMERASE HOMEOSTASIS
Ngày tải lên :
30/09/2015, 13:41
... levels in breast cancer cells 65 Figure 21 TQ induced co-localisation of -H2AX with telomeres in breast cancer cells 67, 68 Figure 22 Differential gene expression profiles in MDA-MB-231 and MCF- 7 cells ... deficiencies in cell cycle checkpoint function in breast cancer cells 41 3.1.3 Changes in cell cycle protein expressions in TQ-treated breast cancer cells 44 3.2 DNA damaging effects of TQ in normal ... chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39, 40 Figure 11 Growth inhibition of breast cancer cells following 48 h TQ exposure...
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