... obtained node statistics, specifically the number of regulatory inputs (in- degree, kin), the number of target genes (outdegree, kout), and betweenness, measuring the centrality of a gene in the ... highly expressed genes being under stronger purifying selection against both amino acid replacements and synonymous changes, as predicted by the translational robustness hypothesis [20] Further, ... variance in the data, indicating that no single variable dominates the rate of protein evolution for the yeast transcription factor genes The pattern is more complex for YTN2 because the principle...