APPLICATION OF SOMATIC VARIANT ANALYSIS IN CANCER EXOMES

... mesothelioma of the peritoneum XIRP2 Xin actin-binding repeat containing Y or Tyr Tyrosine xvii Chapter One: Introduction 1.1 Somatic theory of evolution and the central role of the genome in cancer ... Inferring mutational processes in a tumor The list of somatic SNVs obtained in variant analysis can be viewed as the end result of X mutational processes operating during the development of the cancer ... identified in 350 protein-coding genes in the human genome representing a quarter century of cancer research (35) A mere years later, the number of protein-coding genes implicated in cancer has...

Factors influencing the application of cost utility analysis in assessing disease management among asian patients

... further investigate the factors influencing the application of CUA in their own countries; and (3) Singapore is among the most westernized of all the Asian countries, but at the same time maintains ... to include the impact from the perspective of the receiver Hence, the ECHO model of assessing outcomes in disease management has been gaining increasing acceptance since its proposal Since the ... the application of CUA in evaluating disease management at least theoretically 1.4 Why explore factors influencing the application of CUA to assess disease management among Asian patients? Despite...

Application of time series analysis in modeling childhood epidemic diseases

... APPLICATION OF TIME SERIES ANALYSIS IN MODELING CHILDHOOD EPIDEMIC DISEASES ZOU HUIXIAO (B.Sc South China University of Technology, China) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE ... stochastic version of the SEIR model (Fine and Clarkson [1982]), Finkenst¨adt and Grenfell [2000] introduced a time series susceptible-infected-recovered (TSIR) model, using a discrete time epidemic model ... susceptible individuals, infected individuals and births A person got infected in biweek t is the result of the contact of that person as a susceptible and an infected individual in biweek t...

Báo cáo khoa học: "Detection of Quotations and Inserted Clauses and its Application to Dependency Structure Analysis in Spontaneous Japanese" doc

... based on automatic detection of quotations and inserted clauses Dependency Structure Analysis and Detection of Quotations and Inserted Clauses The outline of the proposed processes is shown in Figure ... Without boundaries of quotations and inserted clauses With boundaries of quotations and inserted clauses (automatically detected) With boundaries of quotations and inserted clauses (correct) open ... Figure 2: Dependency structures of bunsetsus to left of beginning of quotations or inserted clauses For instance, “と思う, to- omou” (think) and “って言う, tte-iu” (say) are used at the ends of quotations...

Báo cáo hóa học: " Review Article Multimodal Pressure-Flow Analysis: Application of Hilbert Huang Transform in Cerebral Blood Flow Regulation" docx

... we review previous applications of MMPF in clinical studies [15, 16], in which the ability and reliability of the method in assessing the CA from spontaneous BPBFV ﬂuctuations during resting ... “Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior,” Proceedings of the National Academy of Sciences of the United States of America, vol 101, no ... 1998 [21] W Huang, Z Shen, N E Huang, and Y C Fung, “Engineering analysis of biological variables: an example of blood pressure over day,” Proceedings of the National Academy of Sciences of the United...

Tài liệu Application of Fuzzy Set Theory in Flexible Manufacturing System Design pptx

... Simulation of scheduling rules in a ﬂexible manufacturing system using fuzzy logic, IEA-AIE96 Ninth International Conference on Industrial and Engineering Application of Artiﬁcial Intelligence ... framework for the design of expert systems Indeed, the design of expert systems may well prove to be one of the most important applications of fuzzy logic in knowledge engineering and information technology ... 5 Application of Fuzzy Set Theory in Flexible Manufacturing System Design 5.1 5.2 A Kazerooni University of Lavisan K Abhary 5.3 5.4 5.5 University of South Australia L H S Luong University of...

Tài liệu Application of Knowledge Management Technology in Customer Relationship Management pptx

... acquiring or generating this knowledge by monitoring the activities of customers and other players in the industry The knowledge codiﬁcation & storage process involves converting knowledge into ... accessing necessary information, resolving inconsistencies in the Knowledge and Process Management retrieved information, ﬁltering away irrelevant and unwanted information, and integrating information ... corporations However, a single view of customers requires tightly integrated applications both within the KM Technology in Customer Relationship Management 15 RESEARCH ARTICLE realm of CRM applications and...

manual on the application of the haccp system in mycotoxin prevention and control pdf

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application of potentiometric stripping analysis

... rapidity and simplicity of electrochemical stripping analysis (ESA), as well as the price of the device give it some priority.7,9 In this work potentiometric stripping analysis was modified to ... contents in the vicinity of the working electrode.3,8 Application of this technique considerably increases the sensitivity of the determination of lead, as the rate of oxidation of the deposit is reduced ... the PSA-iR of lead in the chosen supporting electrolyte, the effects of the time of the electrodeposition of mercury, of the electrolysis potential, of the solution stirring rate and of the constant...

báo cáo hóa học:" An application of principal component analysis to the clavicle and clavicle fixation devices" doc

... [3] The PDM technique represents a training set of landmark data using the Figure Clavicle models Source and target clavicle models mean landmarks and a set of eigenvectors which represent the ... edited and evaluated the manuscript and provided clinical relevance and guidance for the study All authors read and approved the final manuscript Competing interests The authors declare that they ... this article as: Daruwalla et al.: An application of principal component analysis to the clavicle and clavicle fixation devices Journal of Orthopaedic Surgery and Research 2010 5:21 ...

báo cáo khoa học: "A rare presentation of Pulmonary Lymphangitic Carcinomatosis in cancer of lip: case report" docx

... Yang SP, Lin CC: [Pulmonary lymphangitic carcinomatosis] Taiwan Yi Xue Hui Za Zhi 1968, 67(9):361-74 Zhang K, Huang Y: [Clinical features and diagnosis of pulmonary lymphangitic carcinomatosis] ... option in PLC is with chemotherapy Cisplatin have been found to be effective [11] Conclusion Pulmonary Lymphangitic Carcinomatosis may also occur rarely in patients with oral cancers as seen in our ... malignancy in the lung, pulmonary sarcoidosis and hypersensitivity pneumonitis HRCT is the modality of choice for confirmation of the diagnosis The findings in CT scan are - thickening of interlobular...

báo cáo khoa học: " Future medical applications of single-cell sequencing in cancer" pot

... Medical applications of single-cell sequencing (a) Profiling of rare tumor cells in scarce clinical samples, such as fine-needle aspirates of breast lesions (b) Isolation and profiling of circulating ... through single-molecule sequencing, by requiring lower amounts of input DNA In summary, the future medical applications of singlecell sequencing will be in early detection, monitoring CTCs during ... detection using circulating tumor cells Another major clinical application of single-cell sequencing will be in the genomic profiling of copy number or sequence mutations in CTCs and disseminated...

báo cáo khoa học: " Minimally invasive application of botulinum toxin A in patients with idiopathic rhinitis" doc

... rhinorrhea than steroid injection [18] Shaari et al [19] demonstrated a decrease in experimentally induced rhinorrhea in dogs after placing gauze with BTA into the nasal cavity BTA has been injected in ... influence of botulinum toxin type A on vasomotor rhinitis and morphological study Lin Chuang Er Bi Yan Hou Ke Za Zhi 2003, 17(11):643-5 Rohrbach S, Laskawi R: Minimally invasive application of botulinum ... synthase-immunoreactivity A neuromodulating system independent of peripheral nasal gland denervation in guinea pig nasal mucosal tissue after treatment with botulinum toxin type A ORL J Otorhinolaryngol...

Báo cáo y học: "Clinical review: Specific aspects of acute renal failure in cancer patients" pot

... reported with many anti -cancer agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly, the association ... overview of this problem Acute renal failure related to intra -renal or extra -renal obstruction Acute tumor lysis syndrome Tumour lysis syndrome (TLS) is a potentially life-threatening complication of ... during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this setting is the hepatic sinusoid, and the resulting clinical syndrome is called...

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