... a-actinin, either in direct contact or in a complex including the two proteins. In conclusion, our study proves the interaction between a-actinin and calpain 1 and locates binding motifs withinregions ... to the origin of interactions[9,10,12,27] with the targets, the stability of complexes in the resting stage [3,48] and the activation state [7,33] of the binding calpain. The topology of the interface ... The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton Fabrice Raynaud1, Chantal Bonnal1, Eric Fernandez2, Laure...