cocaine and its metabolites in urine

Hydraulic modeling of open channel flows over an arbitrary 3-d surface and its applications in amenity hydraulic engineering

Hydraulic modeling of open channel flows over an arbitrary 3-d surface and its applications in amenity hydraulic engineering

Ngày tải lên : 06/11/2012, 10:35
... depth-averaged model in a nonorthogonal curvilinear coordinates for prediction of flow pattern in meandering channel with 60 o and 90 o bend, and also with compound meandering channel. In this study, ... surface profile into vertical intake. In this regard, the model showed its applicability in computing the flow into intake with air-entrainment. The model was also applied to investigate the ... classified into two groups namely: the depth-averaged models in Cartesian coordinate system and the depth-averaged models in generalized curvilinear coordinate system. The basic assumption in deriving...
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Expansion and its realization in the short story “the law of life” by jack london

Expansion and its realization in the short story “the law of life” by jack london

Ngày tải lên : 29/01/2014, 14:44
... “field, tenor and mode”. Field, tenor and mode determine the experiential meaning, interpersonal meaning and textual meaning, respectively. In order to understand a text, apart from its register, ... defining (restrictive) and non-defining (non-restrictive) relative clauses. According to Halliday (1994: 227) in terms of meaning, these clauses do not define subsets, in the way that a defining ... main character’s point of view. He is an old man left in a clearing by his tribe and his son with only a fire and some wood to burn in a few hours. And during this short moment he realized and...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Ngày tải lên : 14/02/2014, 19:20
... with GST-CD2 (MAP2 v-KIND binding core). Input (cerebellum) GST v-KIND KIND1 v-KIND KIND2 Spir-2 KIND PTPN13 KIND Input (MAP2) GST v-KIND KIND1 v-KIND KIND2 Spir-2 KIND PTPN13 KIND PD from cerebellar ... stain) EGFP EGFP-KIND2-1 EGFP-KIND2-2 EGFP-KIND2-3 EGFP-KIND2-4 EGFP-KIND2-5 EGFP-KIND2 EGFP-KIND1 KIND2-1 487 KIND2-2 521 KIND2-3 555 KIND2-5 589 KIND2-4 488 456 620 KIND2 v-KIND + + + – – Interaction EGFP EGFP- KIND2-1 Input IB: ... the v-KIND-MAP2 interaction within cells. The MAP2-binding core module of v-KIND is involved in targeting to neuronal dendrites and dendrite growth We next investigated the MAP2 binding core of v-KIND...
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Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx

Tài liệu Báo cáo khoa học: A novel splice variant of occludin deleted in exon 9 and its role in cell apoptosis and invasion docx

Ngày tải lên : 18/02/2014, 18:20
... In Chang cells, stained occludin was observed in the cytoplasmic region. Additionally, in Occ WT -overexpressing Hep3B and Huh7 cells, regions stained with antibody to hem- agglutinin (HA), indicating ... level increased in Occ WT -overexpressing cells, and that 2-APB inhibited the effects of Occ WT . Therefore, the increase in intracellular calcium may explain the induction of apoptosis and reduction ... findings, our research provides new insights into the role of exon 9 in the regulation of apoptosis and invasion in liver cell lines. A B Fig. 7. Effects of occludin shRNA on apoptosis and invasiveness....
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx

Ngày tải lên : 19/02/2014, 06:20
... of copper binding could still allow domain swapping to occur. It is of interest that a N-terminally truncated pri- on protein, lacking the copper binding domain is cap- able of domain swapping and forms ... places, but in particular, stefin B has a number of histidines in the C-terminus (box in Fig. 1) at sites: 92, 75, 66 and 58. As histidine residues are central to copper binding in many proteins they ... fibril formation of this protein is diminished in presence of Cu 2+ ions. Another interesting finding is that copper binding gets less strong at pH 5, under fibril promoting conditions and that a mutant,...
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Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx

Tài liệu Báo cáo khoa học: Biochemical characterization of human 3-methylglutaconyl-CoA hydratase and its role in leucine metabolism docx

Ngày tải lên : 19/02/2014, 07:20
... mutations in the AUH gene. This indi- cated that AUH, in addition to its RNA binding func- tion, must play an important role in leucine catabolism. AUH was overproduced in E. coli and characterized by ... using crotonyl-CoA as a substrate [15]. The gene encoding this bifunctional protein was named AUH (‘AU bind- ing homolog of enoyl-CoA hydratase’). The RNA- binding activity of the human protein ... For the kinetic characterization of AUH described in the work at hand, AUH was overproduced in Escherichia coli as a maltose binding protein fusion (MBP-AUH). The complete AUH gene (producing MBP-AUHp40...
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Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt

Tài liệu Báo cáo khoa học: Inhibitory properties of cystatin F and its localization in U937 promonocyte cells ppt

Ngày tải lên : 19/02/2014, 17:20
... dynamic and complex class of vesicles, in which lysosomal cath- epsins are distributed in a nonrandom manner. Murine J774 macrophages concentrate cathepsin H in early endosomes and cathepsin S in ... proline in cystatin F, thus partially explaining the overall lowered affinity of cyst- atin F for these enzymes. Proline in the S 2 site is a fea- ture of human stefin A and cystatins F, S and ... general domain-swapping in the cystatin family [20]. Although both additional cysteines in cystatin F at positions 1 and 37 (cystatin C numbering) can form a disulfide bond [13], the cysteine at position...
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Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

Ngày tải lên : 20/02/2014, 11:20
... P i released min )1 Æmg )1 of protein. Enzyme kinetic study The K m (Michaelis constant) and V max (maximum velocity) values were determined by incubating the diluted recombin- ant proteins in the standard ... deparaffinized and dehydrated using a graded series of alcohol and then rehydrated in NaCl/P i . The slides were blocked for 30 min in 1% H 2 O 2 in NaCl/P i containing 10% ethanol to inacti- vate ... at 26 000 g for 30 min at 4 °C. The supernatants containing recombinant proteins of AsPPase were purified using ProBond TM resin (Invitro- gen) under nondenaturing conditions and subsequently eluted...
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Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf

Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf

Ngày tải lên : 06/03/2014, 22:21
... erythrocytes, and the difference between acetylcholinesterases of kid- ney and erythrocytes in the extent of binding with the lectins concanavalin A, Lens culinaris agglutinin (LCA), and Ricinus communis ... nicotinic receptors [19], amyloid b-peptide and presenilin-1 [20], neuronal enolase, the scaffold protein RACK1 and protein kinase C [21], the corepressor CtBP [22], and Ran-binding protein [23]. ... of Alzheimer’s disease in the brain in vivo. Neurobiol Aging doi:10.1016/j.neurobiolaging.2010.04. 028. 26 Vidal CJ (2005) Expression of cholinesterases in brain and non-brain tumours. Chem Biol Interact 157–158, 227–232. 27...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf

Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf

Ngày tải lên : 07/03/2014, 12:20
... resol- ving cysteine (Cys-S R ). In typical 2-Cys, S p at the N terminus and S R at the C terminus of the protein belong to different subunits and condense to form an intersubunit disulfide bond; in ... S p peroxidatic cysteine; X unidentified electron donor; S R resolving cysteine; RSH protein or domain with CXXC motif (e.g. thioredoxin). In typical 2-Cys, S p at the N terminus and S R at the C terminus belong ... protein instability caused by oxidative stress conditions, are important in deter- mining the level of Bcp2 protein. Similar results are observed for genes and related proteins involved in oxidative...
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Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx

Báo cáo khoa học: Molecular and functional characterization of a novel splice variant of ANKHD1 that lacks the KH domain and its role in cell survival and apoptosis docx

Ngày tải lên : 07/03/2014, 21:20
... a protein containing a single ankyrin repeat that interacts with HIV-1 viral protein R (Vpr) and we designated this protein as Vpr-binding ankyrin repeat protein (VBARP). This interaction was ... aprotinin, and protease inhibitors leupep- tin, chymostatin, and pepstatin (1 lgÆmL )1 ; Sigma) as des- cribed [14] for 15 min in ice. Cell lysates were centrifuged at 22 000 g for 10 min at ... play an important role in protein–protein interactions. ANKHD1 proteins are known to possess multiple ankyrin repeat domains and a single KH domain with no known function. Using yeast two-hybrid...
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Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc

Báo cáo khoa học: The calpain 1–a-actinin interaction Resting complex between the calcium-dependant protease and its target in cytoskeleton doc

Ngày tải lên : 07/03/2014, 21:20
... a-actinin, either in direct contact or in a complex including the two proteins. In conclusion, our study proves the interaction between a-actinin and calpain 1 and locates binding motifs within regions ... Calp1 binding site in the C-terminal region of a-actinin [56] situates the protease in the vicinity of titin [57] and CapZ [34], two proteins described as a-actinin partners in the Z-line and known ... cytoskeletal proteins [25,51]. Binding interface between Calp 1 and ask was further located in this study. Calpain binding structures were found within the 10 kDa C-terminal domain of the a-actinin molecule....
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Solar and Space Physics and Its Role in Space Exploration doc

Solar and Space Physics and Its Role in Space Exploration doc

Ngày tải lên : 14/03/2014, 10:20
... listed in the right-hand column of Table 2.1, indicates the mission’s objectives, and outlines its relevance to the space exploration initiative. Finally, one-page descriptions of the missions and ... vehicles into ionospheres and atmospheres, communication within and through planetary ionospheres, and survivability in the radiation environments of interplanetary space and within planetary ... weather on humans, instrumentation, and communications and spacecraft systems. To that end, input from space physics observations and analysis will help in modeling and developing predictive capabilities...
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PULMONARY TUBERCULOSIS AND ITS MANAGEMENT IN CLASSICAL UNANI LITERATURE pptx

PULMONARY TUBERCULOSIS AND ITS MANAGEMENT IN CLASSICAL UNANI LITERATURE pptx

Ngày tải lên : 15/03/2014, 03:20
... lean and thin. Body skin is dry and thin. Face turns pale and eyes sink. The facial bones become prominent and bones and skin come in contact due to wasting. Both temporal sink. Clinical features ... days and is of low grade and does not have the symptoms of infectious fever like chills, rigors, thirst, irritability, dryness of tongue and foul smelling urine. The patient becomes lean and ... disease, Sil and the causing agent Ajsame Khabitha (microorganisms). Symptoms and signs Pulse is subtle, firm, continuous and weak. Fever is continuous till morning. Fever is constant and due...
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THE MINE WATER POLLUTION THREAT TO WATER RESOURCES AND ITS REMEDIATION IN PRACTICE pdf

THE MINE WATER POLLUTION THREAT TO WATER RESOURCES AND ITS REMEDIATION IN PRACTICE pdf

Ngày tải lên : 15/03/2014, 16:20
... this decision-making process in practice: Wheal Jane and South Crofty (Cornwall), Quaking Houses (Co Durham), Hlobane Colliery (South Africa) and Milluni Tin Mine (Bolivia). In many cases, particularly ... frequent contaminants are Fe, Mn, Al and SO 4 , with locally important contributions by other metals / metalloids including (in order of decreasing frequency) Zn, Cu, As, Ni, Cd and Pb. Remedial ... 1 THE MINE WATER POLLUTION THREAT TO WATER RESOURCES AND ITS REMEDIATION IN PRACTICE PAUL L. YOUNGER Pollution by mine drainage is a major problem in many parts of the world....
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