the holiday activity books
Cambridge - The grammar activity book (bob obee)
... back.✂✂✂ The Grammar Activity Book Bob Obee PUBLISHED BY THE PRESS SYNDICATE OF THE UNIVERSITY OF CAMBRIDGE The Pitt Building, Trumpington Street, Cambridge CB2 1RP, United Kingdom CAMBRIDGE ... minutesGame time20 minutes8 The Grammar Activity Book Map of the book KEY : E=ELEMENTARY; P=PRE-INTERMEDIATE; I=INTERMEDIATE; U=UPPER-INTERMEDIATE Activity title Language focus Level ... lives.During the game, each learner will assume the identity of the animal onhis/her card.3 The aim of the game is to be the first learner to cross off all the phrases onhis/her Bingo card and tell the...
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Tài liệu Báo cáo khoa học: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid ppt
... antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid Bilal A. Azakir, Guillaume Desrochers and Annie AngersDe´partement ... tBid levels and the ubiquitin ligase activity of Itch. In this study, we first examined the ability of Itch tointeract with Bid and tBid. We found that Itch specifi-cally interacts with tBid, but ... proteins Bim and Bak and the C-terminal fragment of Bid. The ubiquitin ligases responsible for the ubiquitylation are in most cases not known [44].Here, we have identified Itch as the ubiquitin ligase responsible...
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Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... 945 The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation Heath Ecroyd and John A. CarverSchool of Chemistry and ... signifi-cantly increased the chaperone activity of aB-crystallin (84 ± 4%) against this target protein. The effect of Arg-HCl on the structure and assembly of aB-crystallin We investigated whether the effects ... Gdn-HClhad no effect on the chaperone activity of aB-crystal-lin against the DTT-induced aggregation and precipi-tation of insulin.ACBFig. 2. aB-crystallin protects against the DTT-induced aggregation...
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Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the structure of exchanging BS-RNase(1BSR) ... Nter are the C-terminal and N-terminal structural regions,respectively, of the two A and B monomers of the dimeric RNase. The black circle between the monomers indicates the mass center of the dimer.E. ... ª 2006 The Authors Journal compilation ª 2006 FEBS 3693 The role of electrostatic interactions in the antitumor activity of dimeric RNases Eugenio Notomista1, Jose´Miguel Manchen˜o2,...
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Tài liệu Báo cáo khoa học: Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf
... half-life of dissociation of 36 –105 min[15]. The oxidation of elafin and trappin down-shifts the half-life of there complexes with NE to % 1 .3 1.8 min. On the other hand, the oxidized inhibitor–Pr3complexes ... experiment).Table 3. Theoretical and observed inhibition of the elastolytic activ-ity of neutrophil elastase (NE) and proteinase 3 (Pr3) by native and N-chlorosuccinimide oxidized elafin and trappin. ... 87 .3 25.0 Trappin Native 99.0 88.5 Oxidized 84.0 30 .5Pr3 Elafin Native 98 .3 55.0 Oxidized 76 .3 10.0 Trappin Native 98.0 80.0 Oxidized 70.0 19.0Inhibition of elastase and proteinase 3 by elafin...
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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx
... usingIMAGEQUANTsoftware, and depurination was calculated by relating the amounts of the small aniline-fragment and 5.8S rRNA and expressingvalues as a percentage.Reassociation and quantification of ... quantitative activity assays of these RTA variants, was not achieved. Toassess whether substitution at Asn78 with Ser changed the catalytic activity of RTA, the N-glycosidase activity of RTAN78S against ... werecarried out for each individual atom. Data collection and refinement statistics are given in Table 1.Assay of the N-glycosidase activity of ricin A chain variants The activity of each of the...
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Tài liệu Báo cáo khoa học: The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site docx
... Mapping of ATP and pNPP binding sites of the Na pump (Eur. J. Biochem. 271) 3927 The phosphatase activity of the isolated H4-H5 loop of Na+/K+ ATPase resides outside its ATP binding site Rita ... IIand its position in the binding site was optimized.ResultsEffects of truncation of the cytoplasmic H4-H5 loop of the a subunit of Na+/K+ ATPase on TNP -ATP binding andp-nitrophenylphosphatase ... at the ATP and pNPP sites on the N-domain of the H4-H5 loop of Na+/K+ ATPase. The models u sed for (A–D ) are the same a sin Fig. 5. (A) and (C) This comparison of pNPP binding to the ATP...
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Tài liệu Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy docx
... uoro-substituted diol-based HIV protease inhibitors Ortho-uorinated and meta-uorinated P1/P1Â-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyJimmy ... difluoro-substitutions at the ortho and meta positions on P1/P1Â-benzyloxy side groups of sym-metric diol-based protease inhibitors preserve the b indingefficacy and significantly improve the antiviral potency.Materials ... com-plexed to HIV p roteas e. Compared w ith th e nonsubstitut edanalog, the fluoro inhibitors have improved the antiviral activity and retained the binding efficacy. The flexibility of the target...
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Tài liệu Báo cáo khoa học: Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) doc
... MINIREVIEW Second messenger function and the structure–activity relationship of cyclic adenosine diphosphoribose (cADPR) Andreas H. GuseUniversity Medical Center Hamburg-Eppendorf, Center of Experimental ... between the base adenine(or hypoxanthine) and the diphospho-bridge, as theycan be replaced by much simpler ether strands. Theseether strands mimic the distance between the nucleo-base and the ... diphosphoribose. The development of novel cADPR analogues revealed new insights into the structure–activity relationship. Substitution of either the northern ribose orboth the northern and southern ribose resulted...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia C. Vijayasarathy1,*,†, ... though the catalytic efficiency of the enzyme (TN for cytochrome c oxidase) remainednearly the same. Increased glycolytic flux and alterations in the kinetic characteristics of the CytOX might be the ... USA The effects of physiologically relevant hypoxia on the catalytic activity of cytochrome c oxidase (CytOX), mito-chondrial gene expression, and both nuclear and mito-chondrial encoded CytOX...
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Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... chemistry of iron( III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom Solange de Lauzon1, Daniel Mansuy1and Jean-Pierre ... possibilities for the binding of ligands on the iron of Fe(porphyrin))13G1 0 complexes: (A) binding of H2O2 on the iron of 13G10-(Fe(ToCPP), (B) bind ing of two CN±ligands on the iron of 13G10-(Fe(ToCPP), ... the antibody and particularlyto appreciate the size of the cavity left around the iron atom and which kind of ligands it can accommodate; second, tomeasure the in¯uence of an axial ligand of...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
... Integrin a3 gene promoter (Eur. J. Biochem. 269) 4527 Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity Takumi ... MyoD/E-box binding factors. The introduction of mutation in one of the Ets-bindingsequences greatly decreased its promoter activity, suggestingthat the transcription of the a3 integrin gene in these ... characteristic feature of the a 3integrin gene among integrin a subunit genes.Fig. 2. Flow cytometric analysis of the expression of the integrin a3 subunit in gastric carcinoma cells. Profiles of control...
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Tài liệu Báo cáo khoa học: The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments pptx
... The molecular surface of proteolytic enzymes has an important role in stability of the enzymatic activity in extraordinary environments Youhei Yamagata1, Hiroshi ... near the C-terminal region on the opposite side of the N-terminal region on the molecular surface. In the wild-type enzyme, the side chain of Asp266 interacted with the amino group of the main ... conformational changeson the surface. On the other hand, anionic surfactants suchas SDS and LAS bind to the surface regions of protein, and the surface regions would be unfolded and removed from the core...
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Tài liệu The Danish History, Books I-IX docx
... but the chronicle of Roskild, the necrology of Lund, the register of gifts to the cloister of The Danish History, Books I-IX, by 2 The death of Balder led Woden to seek revenge. Hrossthiof the ... to thee that shall tame the rage of wild beasts, and crush with fierce mouth the fleet The Danish History, Books I-IX, by 50 men's doings of which he learnt." The latter books are, therefore, ... andbroke into the following strain: The Danish History, Books I-IX, by 46 encompassed huge boulders instead of scrolls, borrowing rocks for the usage of books. Nor may the pains of the men of Thule...
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the holiday activity books
... are mixed in.Heat the pan and mix together as the butter melts.Add the oats.Ask an adult to help with the hot pan.1415Ask an adultto help with the oven.Divide the ball into 16 ... with the oven.Sprinkle flour onto the surface to stop it sticking.Making the cookiesMakes 8–10 cookiesWish you were here!1 Rub it togetherPut all the ingredients in the bowl and rub them ... sugarSet the oven to 170˚C, 325˚F, Gas mark 34 Place on the trayGrease a baking sheet then carefully transfer the dough onto it. The cookies are now ready for the oven.5 Bake then cool...
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