... critical role for aIIbb3 in promoting platelet lamellipodia formation on CRP, thrombin and on fibrinogen, but that out-side -in signalling by the integrin is not required for lamellipodia formation ... necessary for platelet lamellipodia forma-tion on CRP, thrombin and fibrinogen, but that thrombin is able to mediate lamellipodia formation in the absence of outside -in signalling from the integrin. The ... for this response.ResultsMorphological changes of human platelets on fibrinogen, CRP and thrombin The three ligands fibrinogen, CRP and thrombin sup-port platelet adhesion and lamellipodia formation...