Báo cáo y học: "Summary The claudin multigene family encodes tetraspan membrane proteins that are crucial structural and functional components of tight junctions, which have important roles in regulating para cellular" pdf
Báo cáo y học: "Summary The claudin multigene family encodes tetraspan membrane proteins that are crucial structural and functional components of tight junctions, which have important roles in regulating para cellular" pdf
... 3.67. Claudin- 10a Claudin- 10b Claudin- 15 Claudin- 11 Claudin- 18a Claudin- 18b Claudin- 12 Claudin- 16 Claudin- 21 Claudin- 22 Claudin- 24 Claudin- 23 Claudin- 1 Claudin- 7 Claudin- 19b Claudin- 19a Claudin- 2 Claudin- 14 Claudin- 20 Claudin- 3 Claudin- 4 Claudin- 6 Claudin- 9 Claudin- 5 Claudin- 8 Claudin- 17‘Non-classic’ ... components of tight junctions, which have important roles in regulating para-cellular permeability and maintaining cell polarity in epithelial and endothelial cell sheets. In mammals, the claudin family ... beginning to unravel the roles of proteins in TJ formation and function. The large number of claudin proteins and the heterogeneity in their patterns of expres-sion emphasize their crucial roles...
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Báo cáo y học: "Several clinical interests regarding lung volume reduction surgery for severe emphysema: meta-analysis and systematic review of randomized controlled trials." docx
... mortality in 3 months (including Fishman’s study); B: mortality in 6 months; C: mortality in 12 months(including Fishman’s study); D mortality in 3 months (excluding Fishman’s study); E mortality ... reducing the degree of hyperinflation, therefore improving mechanics of diaphragm and chest wall, (3) reducing heterogeneity, (4)increasing work of breathing, and improving of alveolar gas exchange ... Perfusion of the lungs using scintigraphy and medical isotopes. Q is the symbol for perfusion which represents the movement of blood through the arteries that supply the lung. Author Year...
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Báo cáo y học: " First Dominique Dormont international conference on "Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections" pdf
... observed during the post-acute phase of SIVagm infections may be controlled by the early induc-tion of anti-inflammatory cytokines, as observed in thisstudy.HIV infection: role of IL-7 in immune ... HIVinfection of the thymus induced the upregulation of MHC-I in thymocytes, correlated with increases in HIVRNA levels and the development of single-positive CD8low(SP8) thymocytes. Following ... showed that the production of ET-1 by brain endothelial cells in response to HIV-1 leads todisruption of the BBB by the pro-inflammatory cytokines(IL-1, IL-6 and IL-8) produced by astrocytes....
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Báo cáo y học: "Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop" ppsx
... supported by the Division of AIDS, the National Institute of Allergy and Infectious Diseases, the National Institutes of Health. The views contained in this report are those of the presenters and ... leukocyteswere detected in the gut mucosa. After treatment of the mice with progesterone, the mice exhibited thinning of the vaginal epithelia and could be infected by the vaginalroute with HIV-infected ... used to inves-tigate the in vivo effects of HIV infection on other organs,including the brain. The Goldstein group demonstrated that microglia and astrocytes from the JR-CSF/hu-cycT1mice are more...
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Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certainly, at the University of ... MET systems are highly complex and inadequate or incomplete MET implementation may have reduced the likelihood of demonstrating a benefit. After the education period, the maintenance of the ... called in only 30% of cases when criteria for activating the MET were fulfilled, suggesting that many opportunities for early intervention were missed. Like the trauma systems that preceded them...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... is increasingly used in all fields of medicine but is often poorly understood and incorrectlyapplied. Critical Care is therefore launching a series of articles aimed at providing a simple introductionor ... to use and the theory and assumptions behind them.This series does not claim to be a complete course in medical statistics. There are many useful introductory textsEditorialIntroducing the Critical ... Available online http://ccforum.com/content/6/1/003 The science of statistics is increasingly employed in all fields of medicine. Statistical techniques are used not only byacademics and clinicians...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... Eaalmost the same as in the caseofthenativeenzyme(Table1).Thermal inactivation of mutant and wild-type enzymes In order to investigate the effects of mutations on the stability of psychrophilic ... resulted in an enzyme with slightly lower stability.On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores the stability of the protein producing ... efficiency of the enzyme, the cold adaptation of the enzyme could not beattributed to the presence of the Gly cluster in this element. The present study supports the idea that the Gly cluster,in...
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Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... guanidine hydro-chloride (GdnHCl), urea or elevated temperatures, theydestroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc-ture ... assignmentto the protein sequence was possible.RNase A activityTo determine whether the differences in the changes of the tertiary and secondary structures are reflected in the activity of RNase ... result in a rigidity of the loop and, hence, to a proteolytically lesssusceptible state of the RNase A molecule without affecting the overall structure of the protein. Interestingly, the stabilization...
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Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... residue for the final family isgiven in Fig. S1. Fig. 3A shows the family of 40 structures and Table 1 contains a summary of statistical data indica-ting the quality of the 40 models and the average ... where the side-chains of the hydrophobic part of the helix play a key role in receptor binding and activa-tion [54], and the 20–41 region, where side-chains have aprominent role in structural ... imposed by the steric hindrance that arises fromits gem-dimethyl group. The torsion angles for the main-chain conformation of Aib15 in the family of 40 energyminimized structures are calculated...
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Báo cáo Y học: Modeling the three-dimensional structure of H+-ATPase of Neurospora crassa Proposal for a proton pathway from the analysis of internal cavities pptx
... formed by six r esidues, nearly all of which are located on M4. This site is formed by main-chaincarbonyl oxygen of Val304, Ala305, and Ile307 on M4; byside-chain oxygens of Glu309 on M4 and of ... point that these data do not provideinformation on the precise boun daries of transmembranesegments but rather on the regions initiating or impairinginsertion of a segment in the membrane. Therefore, ... secondary structureassignments from the coordinates of the template. The domain displaying the highest sequence s imilaritybetween the t arget and template proteins extends from the N-terminus of...
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