... speculate that the carriage of the C+1354T SNP dampens the mechanisms that sustain platelet aggregation and SScvasculopathy [2,4], once they have been triggered via otherbiological pathways. ... exploratorypoint of view, the His452Tyr substitution was not associatedwith any of the following: the disease subset, the anticorpalstatus, age at the onset of the disease, past history of ... tointerrupt their ongoing therapy. Secondly, SSc platelets showan activated phenotype that that would have been a significantconfounding factor in the analysis of platelet function [5-7].Statistical...