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Báo cáo y học: " Delayed neuropsychological sequelae after carbon monoxide poisoning: predictive risk factors in the " potx

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Báo cáo y học: "Prevalence of Overactive Bladder, its Under-Diagnosis, and Risk Factors in a Male Urologic Veterans Population"

... Publisher. All rights reserved Research Paper Prevalence of Overactive Bladder, its Under-Diagnosis, and Risk Factors in a Male Urologic Veterans Population Wellman W Cheung1, William Blank1, ... prevalence of OAB in urologic male veterans popula-tion, the need for OAB screening, and risk factors for OAB. METHODS An IRB-approved self-administered question-naire on urinary symptoms was given ... of OAB in this population is under-diagnosed and under-treated. Key words: overactive bladder, OAB, incontinence, male, urology, veterans INTRODUCTION Recent international population and non-population...
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Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y pot

Báo cáo Y học: Amphipathic property of free thiol group contributes to an increase in the catalytic efficiency of carboxypeptidase Y pot

... designed to maintain hydrophobicity and Gly, Ser, Asp andHis mutants to provide hydrophilicity. The catalytic roles of Cys341 in carboxypeptidase Y are examined by comparing the kinetic parameters of ... the thiol group (Cys341) is involved in substrate binding at the S1 subsite and in maintaining the width and depth of the S1 subsite; (b) the rearrangement of the S1 subsite induced by the interaction ... scenario in which the hydrophobicity of the SH group of Cys341 is importantfor substrate binding and maintaining the solvent-accessiblecavity at the S1 subsite.However, in the case of the transition...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku- 80 subunit is necessary for basal transcription of the WD gene Won ... Immunoblot analysis and EMSAs showed that the MREa-binding proteins are immunologically rela-ted to the Ku proteins. To study further the functionalsignificance of these Ku- related proteins in transcriptionalregulation ... using syntheticMREa and an oligonucleotide containing the binding site for transcription factor Sp1 revealed the presence of nuclear factors that bind specifically to MREa. Two MREa-bindingproteins...
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Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx

Báo cáo Y học: Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I pptx

... Importin a binds to an unusual bipartite nuclear localization signal in the heterogeneous ribonucleoprotein type I Maria G. Romanelli and Carlo MorandiDepartment of Mother and Child, Biology ... specialized in their efficiency to transport different nuclear proteins [59].It will be interesting to analyze the binding specificity of the different types of importin a toNLD-INLSandtotheputative ... strongly to importin a and the bind-ing is diminished or eliminated even if only one of the twobasic stretches are mutated. The affinity of the importin- targeting sequence interaction is a critical...
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Báo cáo Y học: Function and cellular localization of farnesoic acid O -methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis ppt

Báo cáo Y học: Function and cellular localization of farnesoic acid O -methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis ppt

... acid O- methyltransferase in M. ensis and is the first demonstration of the biological function of this gene. The refolding of the protein during renaturation isimportant for the function of the ... J. Yagi2 and S M. Chan11Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China;2Department of Zoology,University of Toronto, Ontario, Canada;3Department of ... may also be involved in other physiological processes apart from its role in repro-duction and metamorphosis. Further, the specific cellular localization of FAMeT in the X-organ-sinus gland complexsuggests...
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Báo cáo y học: "A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting" pptx

... 9:35http://www.annals -general- psychiatry.com/content/9/1/35Page 2 of 9 aripiprazole in a general outpatient psychiatric practicesetting and to evaluate the effectiveness of aripiprazole in a Taiwanese patient ... effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting. Annals of General Psychiatry 2010 9:35.Submit your next manuscript ... randomized,double-blind, placebo-controlled, study of the efficacy and safety of aripiprazole 10, 15 or 20 mg/day for the treatment of patients with acute exacerbations of schizophrenia. J Psychiatr Res...
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Báo cáo y học: "β Treatment with recombinant interferon-β reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis" ppt

... DahaMR, Kluin PM, Meinders AE, Tak PP: Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis. ... protein for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis was induced in DBA/1 mice.At the first clinical sign of disease, mice were given dailyinjections of recombinant ... treatment. *Statistically significant difference. SEM, standard error of the mean.Figure 2Representative histologic staining (hematoxylin and eosin; ì100) of the ankle joints in mice with collagen-induced arthritis...
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Báo cáo y học: "Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction" potx

... times that in the control synovium. This finding sug-gests that in OA and RA, the protein expression of hyaluronidase- 2 in the synovium is increased and the hyaluronan digestion by hyaluronidase- 2 ... the messages for hyaluronan synthase- 1, -2, and -3 and hyaluronidase- 1, -2, and -3 in the synovium of knees in osteoarthritis (OA) and rheumatoid arthritis (RA)Relative expression levels of the ... weight of hyaluronan in the joint fluids are reduced in osteoarthritis and rheumatoid arthritis. To elucidate the underlying mechanism, we analyzed the message expression of three isoforms of hyaluronan synthase...
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Báo cáo y học: "Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis" potx

... may interact directly with fibroblast-like cellsand through this interaction form part of a signalling loopthat ultimately results in the maintenance of localinflammation. Consequently, the ... directly to the pathogenesis of synovial inflammation and jointdestruction has seen a ‘revival’ over the last couple of years [6,7]. This is mainly due to the observation thatpassive transfer of ... Severallines of evidence suggest that, unlike normal synovial fibroblasts or OASFs, RASFs exhibit features of stableViewpointDirect interaction of immunoglobulins with synovial fibroblasts: a missing...
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Báo cáo y học: "Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis" doc

... butenzymatically inactive (DPP6, DPP10). In some instances, the DPPIV activity is clearly intrinsic whereas in others the nature of the DPPIV activity remains debatable. In these latter cases,DPPIV ... would include the systemicadministration of DPPIV inhibitors to reduce circulatingactivated T cell activity with direct injection of recombinantDPPIV into the inflamed synovium to inactivate ... role in allowing the activated T cells toextravasate into the extracellular space. Once in the vicinity of the synovium, the DPPIV activity would be able to initiateamino-terminal degradation of...
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Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps

... the synovial lining is where TGF- β induces synovial fibrosis, by co-transfection with Smad7, the lining appeared tobe less sensitive to TGF- β-induced fibrosis. The reduction of TGF- β-induced fibrosis ... deal of the TGF- β-induced synovial fibrosis. Combining Smad7 and TGF- β resulted in a higher PG synthesis after IL-1 insult thandid TGF- β alone. This is likely due to the reduced synovial fibrosis ... every single one of the synoviallining cells and thereby fully block the TGF- β-induced fibrosis. We have previously demonstrated that blocking TGF- β withAd-Smad7 in OA resulted in reduction of...
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Báo cáo y học: "Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan" potx

... W,Tomlinson IP, Carter NP: Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res 2004, 64:4817-4825.15. Nakao K, Mehta KR, Fridlyand ... diversities in CRC transcriptprofiles between Caucasian and Han Chinese populations.Additional file 6: The combined analysis of copy number alterations(CNAs) and gene expressions. 1,515 genes showing ... are distin ctly differ-ent, and they tend to have older age onset of cancer and female predominant. For rectal cancer, the percentage of MSI-H and MLH1 methylation was only 2.8% (9/401) and 1%...
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Báo cáo y học: "Adverse clinical sequelae after skin branding: a case series" pps

... NY, USAEmail: Shahzad Raza* - shahzad.raza@nyumc.org; Khalid Mahmood - silsman@hotmail.com; Abdul Hakeem - ahakeem@gmail.com; Sylvie Polsky - spolsky@mit.edu; Anna Haemel - afsheen.raza@gmai.com; ... for many medical con-ditions such as backache, sciatica, arthritis, paralysis,facial palsy, ascites, splenomegaly, lymphadenopathy,jaundice, glaucoma, migraine headaches and sore throat[4]. ... CentralPage 1 of 5(page number not for citation purposes)Journal of Medical Case ReportsOpen Access Case reportAdverse clinical sequelae after skin branding: a case seriesShahzad Raza*1,...
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Báo cáo y học: " Delayed spinal extradural hematoma following thoracic spine surgery and resulting in paraplegia: a case report" pptx

... purposes)Journal of Medical Case ReportsOpen Access Case report Delayed spinal extradural hematoma following thoracic spine surgery and resulting in paraplegia: a case reportChandra JKB Parthiban and ... straining ofparaspinal muscles in the postoperative period after major spinal surgery should be avoided for atleast a few days.IntroductionSymptomatic spinal epidural (extradural) hematoma (SEH) ... literature. Most are the result oftrauma, anticoagulation therapy, vascular anomalies and blood dyscrasias or occur following spinal epidural proce-dures and, rarely, spinal surgery. Increased incidence...
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Báo cáo y học: " Delayed neuropsychological sequelae after carbon monoxide poisoning: predictive risk factors in the " potx

... Grifoni1†AbstractBackground: Delayed neuropsychological sequelae (DNS) commonly occur after recovery from acute carbon monoxide (CO) poisoning. The preventive role and the indications for hyperbaric oxygen therapy in the ... 8 of 8 ORIGINAL RESEARCH Open Access Delayed neuropsychological sequelae after carbon monoxide poisoning: predictive risk factors in the Emergency Department.A retrospective studyGiuseppe Pepe1†, ... poisoning. Brain Inj 1999, 13:229-43.18. Ku HL, Yang KC, Lee YC, Lee MB, Chou YH: Predictors of carbon monoxide poisoning-induced delayed neuropsychological sequelae. Gen HospPsychiatry 2010,...
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