... 44% of patients were responding at the time of their last visitbut chose to leave the study anyway. The patients’ deci-sion to terminate the study reflects either their perceptions of lack of efficacy ... terminated because of perceived lack of efficacy rather than because of adverse events. Irrespec-tive of the study’s power, the efficacy end point of a 20%response defined by the ACR response ... symptomsassociated with the administration of the study drug; theseincluded arthralgias, myalgias, headache, fatigue, chills, and subjective fever. Efficacy The primary efficacy end point of...