... Ritz E: Insulin resistance and hyperinsulinemia are alreadypresent in patients with incipient renal disease. Kidney Int1998, 53:1343-1347.62. Kubo M, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, ... mainly through the kidneys and adecline in GFR increases its level. However, patients with evensevere renal impairment have only minimal hyperuricaemia dueto a significant compensatory increase ... kidney disease in nondiabetic patients, independent of other risk factors [64].Insulin resistance has also been described in patients with RA and may associate with systemic inflammation [44].In...