Báo cáo y học: " State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can''''''''t they clear the infection?" pps
Báo cáo y học: " State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can''''t they clear the infection?" pps
... CF do not deal with this challenge appropriately. In this review, we asktwo questions: Why do the lungs of patients with CF become infected? And why do they not clear theseinfections? Why do ... mucociliary escalator in the non -cystic fibrosis and cystic fibrosis (CF) airwaysFigure 2Schematic Representation of the mucociliary escalator in the non -cystic fibrosis and cystic fibrosis (CF) ... patients with cystic fibrosis become infected and why can't they clear the infection?James F Chmiel and Pamela B Davis*Address: Department of Pediatrics, Case Western Reserve University School...
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Báo cáo y học: " GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cells" ppsx
... serum of patients with idiopathic pulmonary arterialhypertension (IPAH). The aim of the study was to examine the expression and biological roles of GDF-15 in the lung of patients with pulmonary ... contributions to the analysis and interpretation of the data. TW and MMH participated in the design of the study. MG criticallyread and corrected the manuscript. All authors read and approved the finalmanuscript.Competing ... showing astrong signal in the endothelial cell layer (arrows) of a pulmonaryartery with media hypertrophy. The smooth muscle cells(arrowheads) of the remodeled pulmonary artery are lackingsignificant...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"
... on the symptoms of POTS in MS patient. The nature of the severity of symptom improvement and/ or worsening with medication was again subjec-tive and not assessed by a response to HUTT. These ... therapy Response to therapy was subjectively assessed in each patient. None of the patients underwent a repeat HUTT test for objective assessment of symptom re-sponse to therapy. The therapy ... orthostatic tachycardia syndrome (POTS) in patients suf-fering from MS. Methods: The patients were included for analysis in this study if they had POTS with either a prior history of MS or having...
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Báo cáo y học: "A2B adenosine receptor activity is reduced in neutrophils from patients with systemic sclerosis" ppt
... in the vastmajority of cases by the presence of antinuclear antibodies[1]. SSc may affect virtually any organ of the body, includ-ing skin, gastrointestinal tract, lungs, heart, kidneys, and musculoskeletal ... to investigatecoupling of the A2B AR to the adenylyl cyclase pathway. This is the first report of the use of Western blot analysis to confirm the presence of A2A and A2B ARs in human neutrophils. ... Bombardieri1 and Claudia Martini21Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy2Departments of Psychiatry, Neurobiology, Pharmacology and Biotechnology,...
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Báo cáo y học: "DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis" pps
... increase the dose of infliximab. Only a few otherstudies used external criteria for high and low disease activityto study the validity of the Disease Activity Score and the DAS28. In a study performed ... found in the study (see Figure 1 in [1]). Moreover, the use of sensitivity, specificity, and so on, does not reflect the way the DAS28 is used, as one would not use the DAS28 to‘diagnose’ physician ... study, but it is difficult togeneralise the values for sensitivity, specificity, and so on,beyond the study. This difficulty occurs because all values forthese statistics heavily depend on the...
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Báo cáo y học: "Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity" ppsx
... contributionsJYW conceived and designed the study. CFY performed molecular analysis and transient expression, and drafted the manuscript. FJT participated in the design of the study and critically reviewed ... clinical phenotype.Methods: One of the two Han Chinese patients with GM1 presented with the juvenile form, and the other with the infantile form with cardiac involvement. Sequencing of the entire ... intralysosomalactivity/stabilization of both b-galactosidase and N EU1[11,12]. NEU1 catalyzes hydrolysis of the terminal sialicacids of oligosaccharides, glycoproteins and glycolipids[13,14]. The alternative...
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Báo cáo y học: " Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizop" pdf
... time is normally distributed with a mean of 8 weeks and a standard deviation (SD) of 2 weeks in the placebogroupandameanof16weeksandaSDof2weeksin the melatonin group. Finally, the dose at follow-up ... patients whomay gain advantage of the resul ts. This gro up of patients is difficult to treat and therefore often subjectto polypharmacy which may play a role in the reducedlife expectancy of p atients ... binaryindicator of intervention to test the overall effect of intervention and its main effect and interaction with time and time squared. In the analysis of the pattern of benzodiazepine dose,...
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Báo cáo y học: "Cricothyroidotomy for elective airway management in critically ill trauma patients with technically challenging neck anatomy" pps
... simplicity and shortened procedural time of the cricothyroidotomy. The two classic articles by Jackson in 1909 and 1921 con-demned cricothyroidotomy and ‘high tracheostomy’ as the major cause of chronic ... to the larynx and the vocal cords, and that they needed to bechanged to a standard tracheostomy possibly within hours,but certainly within days. This was not always feasible inunstable and ... are that they facilitate transfer from the ICUsetting, they improve oral care and they allow the patient tospeak and eat while on ventilatory support [1].Tracheostomy is no longer the formidable...
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Báo cáo y học: " Increased blood flow by insulin infusion targeting normoglycemia in patients with severe sepsis: friend or foe" ppt
... characteristics, particu larly concerning the severity of the shock, as well as the nonblinded nature of the study, however, may have played a confounding role. Nevertheless, if the increase in forearm ... in the current study by Žuran and colleagues between the forearm fl ow and the insulin doses, largely explained by one outlier, does not suffi ce to conclude that the concomitant prevention of ... on the endothelium. In Žuran and colleagues’ study, the large spread of the achieved blood glucose levels at all studied time points, and the very important overlap between the two study arms,...
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Báo cáo y học: " An open letter to George M Philip, President of the State University of New York At Al" potx
... stance (partly, I’m sure, in relief that they didn’t get the axe them selves) are still going to be on your side in the future? I’m reminded of the fable by Aesop of the Travelers and the Bear: ... faculty would love to talk with you about it - if only you had a Russian department, which now, of course, you don’t.en there’s the question of whether the state legis-lature’s inaction gave you ... put the sowers of discord. ere, as they struggle in that pit for all eternity, a demon continually hacks their limbs apart, just as in life they divided others.e Inferno is the first book of...
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