Báo cáo y học: " Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV" pot
Báo cáo y học: " Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV" pot
... of 15(page number not for citation purposes)RetrovirologyOpen AccessResearch Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung ... wild-type strains of JSRV from around the world. The histologic appearance of the majority of lung tumors in sheep infected with JSRVand in mice expressing only the JSRV Env protein isremarkably ... onco-genesis, including the expression of an oncogene carried by the virus, by insertional activation of host cell onco-genes, or by inactivation of host cell tumor suppressorproteins. The Env protein of...
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Báo cáo Y học: Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae ppt
... significant increase in affinity forduplex DNA [12]. We investigated the junction specificity of MpRuvA by analysing its binding to a Y- shaped junctionand to linear duplex DNA. Like the E. coli protein, MpRuvA ... by the E. coli RuvABC resolvasome complex requires the binding of RuvA to one face of the junction and RuvCto the other [8,9]. Complexes formed by the loading of bothRuvA and RuvC on a synthetic ... highconservation of the sequences forming the pin in th emajority of bacteria with the exception of two Mycoplasmaspecies and one of Ureaplasma. In t he RuvA p roteins fromthese organisms the pin sequence...
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Báo cáo Y học: Barley a-amylase Met53 situated at the high-affinity subsite )2 belongs to a substrate binding motif in the bfia loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate specificity pot
... 63–97; indi-catedbyarrow)isindarkblue.Thecatalyticacids(seeAabove)are colored in yellow. M52AMY2(M53AMY1)andW83TAAare in red(indicated by arrow). Y5 1AMY2and Y8 2TAAare in orange. Otherbinding ... though the rates of hydrolysis of the oligosaccharide substrates greatly decreased, the bindingmode was most probably controlled by the outermost high-affinity subsite )6 and was retained by the ... sites of cyclo-dextrin glycosyltransferase give insight into the mechanisms of transglycosylation activity and the cyclodextrin size specificity.Biochemistry 39, 7772–7780.26. Yoshioka, Y. , Hasegawa,...
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Báo cáo y học: " Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report" pptx
... 4 of 4infiltrates surrounding the vascular structures and dis-persed within the adipose tissue (Figure 2). The infiltratewas comprised of small lymphocytes with clumpedchromatin, indistinct ... lymphocytes being CD3 (+)T-cells. Together, the flow cytometry of the peripheralblood and immunohistoc hemistry of the pericardialtissue were consistent with pericardial involvement by CLL. The ... biopsy (Hematoxylin and eosin stain).Note the focal lymphocytic infiltrate in the pericardial tissueremoved at the time of the subxiphoid pericardial window.Figure 3 A pericardial biopsy (immunohistochemical...
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Báo cáo y học: "Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report" pptx
... lymphocytes being CD3 (+)T-cells. Together, the flow cytometry of the peripheralblood and immunohistoc hemistry of the pericardialtissue were consistent with pericardial involvement by CLL. The ... biopsy (Hematoxylin and eosin stain).Note the focal lymphocytic infiltrate in the pericardial tissueremoved at the time of the subxiphoid pericardial window.Figure 3 A pericardial biopsy (immunohistochemical ... Chronic lymphocytic leukemia is an indolent disease that often presents with complaints of lymphadenopathy or is detected as an incidental laboratory finding. It is rarely considered in the differentialdiagnosis...
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Báo cáo y học: " Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study" pps
... a therapeutic target in AKI. Modulation of these cytokines may reduce the degree of kidney injury itself,as well as the deleterious effects of kidney injury on other endorgans, including the ... is the surgery and bypass itself. Thus, the tim-ing of the insult is clear. Based on our animal studies, wehypothesized that levels of proinflammatory cytokines wouldincrease early after the ... University of Cincinnati School of Medicine, Cincinnati, OH, USA4Section of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati School of Medicine,...
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Tài liệu Báo cáo Y học: Interallelic complementation provides genetic evidence for the multimeric organization of the Phycomyces blakesleeanus phytoene dehydrogenase doc
... 2002understanding of the function and organization of the enzyme complex, the analysis of mutant a lleles of the ge nesinvolved in the biosynthetic pathway c an certainly providevaluable information. In ... required for the association of the different enzyme monomers or for theirinteraction with other membrane proteins. The observed in vitro activation of the enzyme could t hen be explained by adetergent-mediated ... C5, but n ot in strain S442. These observations indicated that while the catalytic activity of the phytoene dehydrogenase in strainS442 is directly affected by the mutation, strain C5 possessesa...
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Báo cáo Y học: S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) ppt
... concentrations were determined by the Bradford assay using BSA as the standard. The following purified proteins were kindly provided by colleagues: the MBP fusion protein of the NBD of the lactococcal ... binding andtransport are located within the transmembrane domains in P-gp and MRP [22–30]. Interestingly, however, twostudies point to the binding of an allocrite by the ATP-binding domain ... explained by assuming the presence of one high-affinity stimulatory binding site, and one low-affinity inhibitory binding site.These sites may be identical to the on and off sites, whichare distinct...
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Báo cáo y học: "Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β" docx
... culturesAnaphase-promoting complex subunit 8Cyclin-dependent kinase inhibitor 3 Kinesin-like protein 1 Selenium binding protein 2Bone morphogenetic protein 4 Cytoskeleton associated protein 2 Kinesin-related protein ... for driving the arthritogenic activities of IL-1.These products include the primary cytokines, chemokines,synthetic and proteolytic proteins associated with the pathol-ogy of OA. The protection, ... mediator with the capacity todrive the key pathways typically associated with the pathogen-esis of OA. As shown here, as well as by others, IL-1 abruptlyshifts the metabolism of the chondrocyte...
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Báo cáo y học: "HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis" potx
... manuscript, the HLA typing and statistics,and also contributed to the writing of the last version of thismanuscript. CLL reviewed the manuscript, the HLA typing andcontributed to the writing of the ... version of this work.MA participated in the study design, the recruitment and eval-uation of patients, and in the writing of the manuscript. CS per-formed the statistical design of the study and ... phenomenon of linkage dise-quilibrium between genes. The latter may explain why someHLA genes originally associated with PsA susceptibility arenow being considered part of the ancestral haplotypes...
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