... o n the m ean hydrophobicity and/or netcharge of the natively unfolded polypeptide. In fact, anyinteraction of such protein with natural ligand affectingmean net c harge and/or mean hydrophobicity ... Instrumentation, Russian Academy of Sciences, Pushchino, Moscow, Russia;2Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USANatively unfolded or intrinsically ... hydrophobicity of the protein could c hange t hese parameters in such a way thatthey will approach values typical of folded native proteins.This hypothesis has been con®rmed by calculation the joint mean...