... shown). The action of HDACi could thereforebe either on the Timp-1 gene itself, or on the expression of a protein(s) required for induction of the Timp-1 gene.Time course of TSA action upon PMA- ... to assess the possibility that the effects of HDACi are secondary, acting to modulate the expression of an intermediate, the requirement fornew protein synthesis in the induction of Timp-1 wasassessed. ... of an additional, functionally overlapping, familymember. However, the function of c-Jun, in mediating the superinduction of PMA-induced Timp-1 expres-sion, appears unique. The effects of...