... cells, synovial monocyte/macro-phages both can respond to inflammatory agents to trans-locate HMGB1 and can be activated by HMGB1 to releaseproinflammatory cytokines. The role of HMGB1 in systemic ... 2007, 11:R122.70. Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, TanakaM, Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto H, Iino S, Taniguchi N, Maruyama I: The N-terminaldomain ... receptors that includeRAGE (receptor for advanced glycation endproducts) as well asToll-like receptor-2 (TLR-2) and TLR-4 and function in a synergisticfashion with other proinflammatory mediators...