... manually analyzed all these 40 modifications in order to verify the effect of the repeats on the resulting pro-teins. In the majority of cases, the reading frame of the origi-nal protein is ... 2).Often these modifications occur in polymorphic human pro-teins, such as the keratin-associated proteins, the VCX /Y pro-teins, the nuclear pore interacting proteins, and the prostate-ovary-testis-endometrium ... regions (UTRs), and coding sequences is reported. For ITRs lying within coding sequences, the length of the ITR unit in base pairs and the effect on the reading frame of the encoded proteins are also...