Báo cáo y học: " Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis" docx
Báo cáo y học: " Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosis" docx
... angiogenesis. The aim of our studywas to investigate the role of ING4 in the pathogenesis of pulmonary fibrosis both in the bleomycin (BLM)-model and in two different types of human pulmonary fibrosis, including ... purposes)Respiratory ResearchOpen AccessResearch Down-regulation of the inhibitor of growth family member 4 (ING4) in different forms of pulmonary fibrosisArgyris Tzouvelekis*1, Vassilis Aidinis2, ... investigate the role of ING4 in the pathogenesis of pulmonary fibrosis by assessing itsexpression both in the bleomycin (BLM)-model and in two different types of human pulmonary fibrosis by usingtissue...
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Báo cáo y học: "Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18–20 April 2004" docx
... inflammatory cytokines such as IL-1 andcauses aggrecan breakdown. Intriguingly, the induction byIL-1 of ADAMTS -4 together with a variety of otherinflammatory response gene mRNAs is inhibited when the chondrocytes ... probably due to inhibition of cyclin D1expression. SOX9 expression is needed for maintenance of the phenotype of mature chondrocytes and itsexpression is inhibited by inflammatory cytokines ... matrix,possibly by perlecan. Damaging the tissue by simplecutting releases the growth factor very rapidly andactivates the chondrocytes. bFGF upregulates synthesis of a number of proteins, but particularly...
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Báo cáo y học: "What is the best site for central venous catheter insertion in critically ill patients" doc
... corrected simply by pulling the catheter back. However,malposition of internal jugular vein catheters in the axillaryvein is frequently reported [3]. In the meta-analysis conducted by Ruesch and ... only 17 wereincluded in the meta-analysis. The meta-analysis populationincluded ICU and non-ICU patients, and no distinction wasmade between catheters inserted for dialysis, pulmonary artery ... Whenmanoeuvred around the bend at the innominate–cavaljunction, the tip of the catheter or its introducer sheath mayerode the endothelium, predisposing to mural thrombosis. The Seldinger technique...
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Báo cáo y học: "Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury" docx
... (metabolite of prostacycline). The levels of the proinflammatory cytokine IL-8 followed the endo-toxin evolution in blood.Endothelin-1 and inhaled nitric oxide The ET-1 in plasma rose rapidly and ... severe pulmonary hypertension may beexplained by higher levels of ET-1. INO, known for its antiin-flammatory properties [22], could attenuate the effect of INOby decreasing ET-1 levels. This may ... severe pulmonary dysfunction at a comparable inflammatory profile.• Endothelin-1 levels correlate with the magnitude of pul-monary hypertension.• Further support is added to the hypothesis...
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Báo cáo y học: "Chiropractic at the crossroads or are we just going around in circles" pps
... the philosophicalunderpinning of finding and correcting subluxations. In summing up, the Presiding Member of the tribu-nal discredited the testimony of one expert witness,Dr. Matthew McCoy, ... make their philoso phy moreaccepta ble in today’ s world by guising scientific rational-ity under the cloak of emotionality. They selectivelyincorporate scientific findings that support their ... the functioning of the neurological system in a variety of ways through a variety of mechanisms; we see suchaltered function as ranging from the Newtonian andquantifiable findings of pain and altered...
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Báo cáo y học: " Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients" docx
... contributionsDD carried out the flow cytometry and was involved in the design of the study and drafting the manuscript. TGperformed the in situ hybridization and conceived of the study. TT carried out ... wasinvolved in drafting the manuscript. PZ, KD and BS con-ducted the clinical part of the study and were involved in the design and coordination of the study. All authors readand approved the ... 30 min. at 4 C, fol-lowed by two incubations in isopropanol (10 min at60°C, 2 min. at 60°C) and air dryed. Rehydration wasachieved by incubation in 70% (vol/vol) acetone for 10min. at 4 C...
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Báo cáo y học: " Cardiovascular stability during arteriovenous extracorporeal therapy: a randomized controlled study in lambs with acute lung injury" docx
... in severity. Whether the severity of ALI was different between the groups may be indirectly evalu-ated by comparing the indices of pre- and post-injury gasexchange. Our data indicate that pulmonary ... our findings and those of other investigators is that the AV shunt opening in our study led to a mortality rate in the smaller lambs, resulting in a difference between the bodyweights of the ... variables before and after induction of lung injuryCMV (n = 8) AV-ECMO (n = 9)Variables Pre-injury Post-injury Pre-injury Post-injuryMinute volume (ml/kg/min) 40 8 ± 79 640 ± 144 * 382 ± 109 561 ± 187*PaO2...
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Báo cáo y học: "Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment" pptx
... JNK, suggesting that the JNKpathway was involved in the acute inflammatory lung injury asfound in the previous study [13,20].Members of the S100A4/FSP1 family have been implicated in cytoskeletal–membrane ... used in our study to focus on the major target involved in the earlyphase of pulmonary fibrosis after ALI. In our study, we alsofound there were similar signaling pathways involved in the early ... permeability, the quantitative and qualitative evaluation of pulmonary fibrosis by hydroxyproline assay and Masson's tri-chrome staining, the positive S100A4/FSP1 staining of epi-thelium...
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Báo cáo y học: "HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat" pps
... first of these maturation inhibitors to gointo clinical trials and inhibits HIV-1 replication by spe-cifically blocking cleavage of CA from p2, one of the final (rate-limiting) steps in the Gag ... mutations in the absence of PI therapycan be explained by compensatory fixation. J Infect Dis 2007, 195:399 -40 9.29. Mammano F, Trouplin V, Zennou V, Clavel F: Retracing the evolutionarypathways of ... respectively.TherelativeRCofthe12site-directedmutantswasassayed by culturing virus in the absence of inhibitor for 14 days and monitoring p 24 production. None of the four resistance mutations had an apparent effect onviral replication in the background...
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Báo cáo y học: "Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models" pot
... and in vivo1OH_Km and 1OH_Vmax for the hydroxylation of MDZ viaCYP3A4/5. Furthermore, the individual 1OH_Vmax varia-bility was linked to the underlying process by comparing the CV% of ... 15, 30 and 45 minutes (the averagelength of time the tablets reside in the stomach in the fedstate) to 52% in 75 minutes (2% being the maximum dis-solution in the intestines). Further, ITZ ... for the hydroxyla-tion, normalized to the mean. There is no correlationbetween the CYP3A5 genotype and the affinity of MDZ toCYP3A (Km) or the rate of hydroxylation (Vmax) in the basal state.Figure...
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