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Báo cáo y học: "Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice" pot

Báo cáo y học:

Báo cáo y học: "Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice" pot

... Zeidler-Erdely et al., Response of the mouse lung tran-scriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice Respiratory Research ... significant lung cytotoxicity and inflammation persisted in the A/J strain, whereasinflammation resolved in the B6 by 7 days [9]. Our lung transcriptome profiling in these mouse strains comple-ments these ... unique insight intostrain- and welding fume-dependent genetic factorsinvolved in the mouse lung response to welding fume. The gene regulation and network interconnectivityreported in this study...
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Báo cáo y học: "CD14 mediates the innate immune responses to arthritopathogenic peptidoglycan–polysaccharide complexes of Gram-positive bacterial cell walls" docx

... target and mediator of the TLR-4-induced sign-aling is the transcription factor nuclear factor-κB (NF-κB),which controls the expression of a variety of proinflamma-tory cytokines, including IL-1, ... findings, CD14 knockout mice hadsignificantly inhibited inflammatory cell infiltration and synovialhyperplasia, and reduced expression of inflammatory cytokines in PG-PS arthritic joints. These ... PG-PS-induced production of inflammatory cytokines The signal transduction pathways activated by TLRs culmi-nate in activation of transcription of defensive genes. The expression of many inflammatory...
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Báo cáo y học: " Construct development: The Suicide Trigger Scale (STS-2), a measure of a hypothesized suicide trigger state" pdf

... describedby Beck. Furthermore, the second principal component,while including elements akin to canonically describedhopelessness, is distinct no tonlybyvirtueofexistingwithin the context of this syndrome, ... attempt.Integration of Principal Component and RegressionAnalysesSeveral of the best-performing items in regression analysisloaded strongly (factor loading values ≥ 0.5) on the principalcomponents. Furthermore, ... and contributed the design and completion of the data analyses. CK assisted in the drafting of the manuscript, performance of the statistical analyses, as well as the coordination of the study....
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Báo cáo y học: "Response to the commentary ‘Pooled indices to measure rheumatoid arthritis activity: a good reflection of the physician’s mind" pdf

... included in the study had long-standing destructive disease (mediandisease duration 10 years) and had previously failed to respond to aggressive therapy, as reflected by a failure to respond to a ... median of four disease-modifying antirheumaticdrugs. Infliximab therapy was for most patients the finaltherapeutic option at the time of the study, and for suchindividuals and their physicians ... appreciation of the patient’s condition and disease activity. Because the analysis presented in our reportwas not planned for in the initial protocol, a post hocamendment to the initial protocol...
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Báo cáo y học: "Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet" ppsx

... zone of liver lobulus. In the periportal zone the detection of GFAP in biliary cells and oval cells, calls other cell types as progenitors of hepatocytes into question under CDEdiet conditions.BackgroundOval ... Further-more, also infiltrating immune cells may contribute to M2-Pk expression demonstrated by our in vitro results. In addition to the early expansion of myofibroblasts [4],we definitely show that ... Accordingly, at different time points of CDE diet the fraction of M1- and M2-type may varyconsiderably.Secondly, M2-Pk reflects the activati on of both ovalcells and sinusoidal cell types as...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx

... data, randomly generated according to the expectedcontingency table (and so satisfying the null hypothesis). The relationship between tissue specificity and phyletic age and function was investigated ... (the number of non-synonymous substitutions per non-synonymous site) to Ks (the number of synonymous substitutions per synonymoussite) was calculated using the codeml program from the PAML 3.13d ... using a contingency table testunder the null hypothesis that function and specificity areindependent of given age. Conceptually, the genes are dividedup according to age and a separate contingency...
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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"

... pharmacokinetics are the drug transporters and the metabolizing en-zymes [7,9]. CYP3A, the primary subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of ... Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. CYP3A5 polymorphisms seem to affect tacrolimus kinetics at a greater degree com-pared to CYP3A4 ones and thereby, ... to transplantation im-proves the individualization of immunosuppressive therapy although epigenetic factors must be taken into account [7]. The aim of the present study was to determine the...
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Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"

... medical condition pertaining to CVS, RS, gas-trointestinal tract, hepatobiliary system, genitourinary system, reproductive system, CNS and psychiatric conditions, and then to specify the name of ... According to the survey, level two was considered to be in the range of ten to twenty-five laughs in one day, and on the situational laughter scale, a rating of four to seven. Clinically, laughter ... history can be obtained by asking the indi-vidual “how many times do you laugh during your regular day?” and have the individual rate their level on a scale of one to ten. Furthermore, other...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice

... marrow and the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and ... Faculty of Medicine, The University of Hong Kong, Hong Kong, China Corresponding address: Prof. C.H. Cho, Department of Pharmacology, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China. ... cytotoxic effect via transfer of its alkyl groups to DNA, leading to cell cycle arrest and apoptosis. The major site of alkylation within the DNA is the N7 position of guanine. Alkylation of...
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Báo cáo y học: "Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary"

... Andrew E. Czeizel Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary Corresponding address: Andrew E. Czeizel Foundation for the Community Control of Hereditary ... 66.83 per 1000 informative offspring in the 1980s and within this, the total rate of major congenital abnormalities was 27.01 per 1000 informative offspring [1,2]. The causes of congenital abnormalities ... proportion of genetic origin is estimated about 25 % of total congenital abnormalities. Mainly two conditions may contribute to a higher total prevalence of congenital abnormalities with genetic...
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