Báo cáo y học: " Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection" potx
Báo cáo y học: " Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue infection" potx
... Virology Journal 2010, 7:361http://www.virologyj.com/content/7/1/361Page 2 of 10RESEARC H Open Access Comparison of the diagnostic accuracy of commercial NS1-based diagnostic tests for early dengue ... compare the performance of the current commercially available NS1-based assays for the early diagnosis (within 7 days since fever onset) of dengue infections. The objectives of this study were:1) ... and severity of the disease on the sensitivity of the tests, and 3) to determine the reproducibility of each diagnostic test.MethodsType of study and sample size calculation The study was a cross...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... several examples of theory being misled by mistaken data. Indeed, early reports of SMGT were compared with the (then contemporary) claims of “cold fusion” in physics [36]. By contrast, the second ... Transfer The genome of retroviruses can be manipulated to carry exogenous DNA. Retroviral vectors (RVVs) are one of the most frequently employed forms of gene delivery in somatic gene therapy [15, ... germline gene therapy. 2. Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have the following...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... indicating that the environ-ment of tryptophan residues is essentially conserved in the mutant enzyme. On the other hand, the absence of majordifferences in the CD spectra of the wild-type and D153Nagmatinases ... weconclude that the lower activity of the mutant may beascribed to the loss of an acceptor hydrogen bond to ametal-bound hydroxide, as a consequence of replacement of a carboxylate oxygen with an ... altered interactions with the substrate or asignificantly altered affinity for the activating metal ion, arenot the explanations for the greatly decreased catalyticactivity of the D153N variant.To...
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Tài liệu Báo cáo Y học: Studies on the nonmevalonate pathway of terpene biosynthesis The role of 2C-methyl-D -erythritol 2,4-cyclodiphosphate in plants docx
... Stereochemistry of the isoprenylation of tryptophan catalyzed by 4-(g,g-dimethylallyl) tryptophan synthasefrom Claviceps, the first pathway-specific enzyme in ergot alkaloidbiosynthesis. J. Am. ... HA-hydrogen of IPP. Inboth cases, scrambling of the label takes place within the IPPpool and the error is then transcribed into the DMAPP pool by the normal action of the isomerase. The validity of the proposed ... 2C-methyl-D-erythritol4-phosphate can be converted into a cyclic diphosphate by the consecutive action of 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, 4-diphosphocytidyl-2C-methyl-D-erythritolkinase...
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Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
... particle density of the polydisperse sol-utes. For the functional dependence between the densityand molar mass of the fractionated emulsion particles,we assumed a spherical monolayer of Myr2Gro-PChosurrounding ... known whether the apoE3 isoform displays a similarphenomenon on the surface of lipid particles.In the present study we develop methods for the characterization of lipid emulsions of well-defined ... differ in fatty acyl chain length,and are therefore more biologically relevant than mono-layers comprised of Myr2Gro-PCho alone [46]. The EggPtdCho/TO emulsions were synthesized by pressureextrusion...
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Báo cáo y học: Advances in the Surgical Management of Chronic Rhinosinusitis" pot
... whoshow evidence of polyps reforming can have these early polyps débrided with topical and/or localanesthesia. Such ongoing cavity “maintenance” canoften keep these individuals out of the operatingroom ... tissuecontraction. Obviously, another indication for revision surgery is recurrent polyp disease that can-not be managed medically or in the office.Technical State of the Art The current state of the art in ... that furthermedical therapy will still be required to managetheir disease but that marsupialization of the eth-moid sinus cavity with surgical widening of the ostia of the secondary sinuses...
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Báo cáo y học: "Developments in the clinical understanding of osteoarthritis" docx
... diseases of aging for whichthere is little, if any, effective treatment. It accounts for moremobility disability in the elderly than any other disease.Symptomatic knee OA affects roughly 12% of ... x-rays have a sensitivity of only about25% for cartilage loss seen on MRI. The x-ray underestimatescartilage loss occurring in the posterior sweep of the femurand often in the upslope of the ... [44]. Thus, some of the heterogeneity of the disease path is likely to be due to the presence or absence of malalignment across the joint.Genetics of osteoarthritis The proportion of OA due to genetic...
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Báo cáo y học: "Developments in the clinical understanding of rheumatoid arthritis" ppt
... consequence of the activation of many cell populationsand, ultimately, of the upregulation of proinflammatory cyto-kines [19,20]. By whichever means they themselves becomeactivated, they induce ... 1Composite indices are the best depicters of disease activity. The degree of disease activityat the start of a disease-modifying therapy is amajor determinant of the disease activityattainable in ... M, Smolen JS:Benefit of very early referral and very early therapy withdisease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis. Rheumatology (Oxford) 2004, 43:906-914.63....
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Báo cáo y học: "Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis" pdf
... sensitivesubstrates for the detection of antibodies in RA. Cleavage of bovine CII with cyanogen bromide yielded CB10 and CB11;these were purified by column chromatography for use in anenzyme-linked ... availability of collagen type II epitopes for bindingwith antibody on the surface of articular cartilage. J Clin Invest1991, 87:1531-1536.37. Kyburz D, Corr M: The KRN mouse model of inflammatoryarthritis. ... preparations of the two major cya-nogen bromide (CNBr) fragments of CII, namely CB10 andCB11, would serve as superior substrates for the detection of antibodies in RA. It was found that the frequency of...
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Báo cáo y học: " Developments in the scientific understanding of lupus" pot
... beenclearly associated with disease activity or response totherapy. The independence of these responses implies the existence of more than one pathway for autoreactivity as wellas sources of autoantigen ... thatinvolve the entirety of the immune system. Some of these maybe genetically determined, whereas others arise secondarilyin response to events such as infection. Not surprisingly,delineation of these ... in nearly any organ system, the kidneys,central nervous system, and endothelium remain majorsources of morbidity and mortality and have been studiedintensively over the past decade.KidneyLupus...
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