Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx

... pseudoreceptor by intercalating in the TGF-` complex and disrupting receptor signaling, thus func-tioning as a naturally occurring dominant mutant of BMP signaling.Tkv In the developing wing disk of ... with Xwnt-8, showing a direct interaction between Frzb and Wnts (84), and Frzb blocks the axis-inducing activity of Xwnt-8 and mouse Wnt-1 when coinjected on the ven-tral side of cleaving embryos, ... functional interaction between BMP-7 and the latent TGF-` bindingprotein family member Fibrillin-2 and suggest that the bioactivity or availability of BMP-7, like thatof TGF-`, may be regulated by interactions...

... PGE2-induced cAMP and inositol trisphosphate accumulation ( 254 ) and cal-cium influx ( 255 ), PGF2_-induced PGE2 synthesis ( 256 ), and PGF2_ or PGE1 - induced interleukin-6synthesis ( 257 ).As ... the pro-duction of insulin-like growth factor-binding proteins-2, -3 and -4 in human bone marrow stromal cells. Eur. J. Endo-crinol. 144, 54 9 55 7.1 75. Schmid, C., Schlapfer, I., Gosteli-Peter, ... Baylink, D. J. and Linkhart, T. A. (1993) 1,2 5- Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteo-blast-like cells in vitro and...

... crest were assessed at 9 .5 13 .5 dpc by using molecular markers. Aretinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1Fig. 5. Analysis of the endogenous ... Standard developmental toxicity bioassays in rodents include a detailed examination of thenear-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stained (alizarinred ... cause ligand-independent activation of the receptor (40), as well as to increase itsresponsiveness to the ligand (42). Mutations in the tyrosine kinase domain (Asn540Lys, Lys 650 Glu, and Lys 650 Met)...

... factorregulation,interferon-a, 203, 204interleukin-1, 202interleukin-4, 202interleukin-6, 202, 203interleukin-11, 203macrophage colony-stimulatingfactor, 200, 201osteoprotegerin, 201RANKL, 200transforming ... loss in aging, 253 – 255 connectivity density, 255 mechanical properties, 256 – 258 micro-computed tomography scandata, 251 – 253 model requirements, 251 morphological anisotropy, 256 prospects, 258 –260overview, ... signaling, 154 , 155 long bone development orchestrationwith Indian hedgehog, 159 –162,166–169 molecular mechanisms, 153 , 154 overview, 149, 150 , 162–1 65 retinoic acid receptor signaling and establishment...