Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
Biochemical, Genetic, and Molecular Interactions in Development - part 3 pdf
... prolyl 4-hydroxylase, prolyl 3- hydroxylase, and lysyl hydrox-ylase, catalyze the formation of 4-hydroxyproline, 3- hydroxyproline, and hydroxylysine residues in -X-Pro-Gly, -Pro-4Hyp-Gly-, and -X-Lys-Gly- ... without leaving the lumen of cisternae. Cell 95, 9 93 10 23. Regulation of BMP, Wnt, and Hh Signaling 1 13 1 13 From: The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and HomeostasisEdited ... chains, called _ chains, and contain at least one unique triple-helical domain withrepeating -Gly-X-Y- sequences in each of the constituent chains. The presence of glycine, the small-est amino...
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Biochemical, Genetic, and Molecular Interactions in Development - part 1 docx
... Wnt ligand binding, glycogen synthase kinase 3` (GSK -3 ` ) is inactivated by a series of kinases and `-catenin (`-cat) accumulates in the cytoplasm and translocates into the nucleus, where it interacts ... at tis-sue and somite boundaries. Development 120, 36 67 36 79.102. Novak, A., Shu, C., and Chungyee, L. (1998) Cell adhesion and the integrin-linked kinase regulate the LEF-1 and `- catenin signaling ... armadillo:roles for wingless signal and zeste-white 3 kinase. Dev. Biol. 166, 5 43 556.86. Rubinfeld, B., Albert, I., and Porfiri, E. (1996) Binding of GSK -3 ` to the APC-`-catenin complex and regulation...
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Biochemical, Genetic, and Molecular Interactions in Development - part 2 potx
... Smad3 and ATF-2 contribute to TGF-`-mediated effects on chon-drocyte differentiation, and both participate in the induction of PTHrP in chondrocytes (36 ). TGF-`is capable of phosphorylating and ... determines different BMP-2 signaling pathways. J. Biol.Chem. 277, 533 0– 533 8. 35 . Knaus, P. and Sebald, W. (2001) Cooperativity of binding epitopes and receptor chains in the BMP/TGFbeta super-family. ... physical and biochemical changes, including a 5- to 10-fold increase in volume and expression of alkaline phos-phatase, type X collagen, and MMP- 13 (1,2). Type X collagen is a short-chain collagen...
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Biochemical, Genetic, and Molecular Interactions in Development - part 4 ppt
... pseudoreceptor by intercalating in the TGF-` complex and disrupting receptor signaling, thus func-tioning as a naturally occurring dominant mutant of BMP signaling.Tkv In the developing wing disk of ... with Xwnt-8, showing a direct interaction between Frzb and Wnts (84), and Frzb blocks the axis-inducing activity of Xwnt-8 and mouse Wnt-1 when coinjected on the ven-tral side of cleaving embryos, ... functional interaction between BMP-7 and the latent TGF-` bindingprotein family member Fibrillin-2 and suggest that the bioactivity or availability of BMP-7, like thatof TGF-`, may be regulated by interactions...
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Biochemical, Genetic, and Molecular Interactions in Development - part 5 docx
... to identify BMP-induced genes. Osx is a novel zinc finger-containing transcrip-tion factor that is specifically expressed in developing bones. Osx contains a proline- and serine-richtranscription ... cytochrome c into the cytosol. Subsequently, BMP-2 increased caspase-9 and caspase -3 , -6 , and -7 activity. Inhibition of caspase-9 activity suppressed BMP-2-induced apoptosis. However, over-expression ... the BMP-2-induced increase in the Bax/Bcl-2 ratio, caspaseactivity, and apoptosis. In contrast, the cAMP-dependent protein kinase A (PKA) inhibitor H89, thep38 MAPK inhibitor SB2 035 80, and the...
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Biochemical, Genetic, and Molecular Interactions in Development - part 6 docx
... osteogenesis in preclinical and clinical contexts (1,11–16). Naturally-derivedBMPs/OPs and recombinant human osteogenic protein-1 (hOP-1), also known as BMP-7, induce osteo-genesis in nonhuman and human ... depending on the experimental design, can (1) main-tain the integrity of the anlagen and the inherent cell and tissue interactions involved in its normal development, (2) allow for analysis of interactions ... divergent responsive-ness in osteoclasts formed in vivo and in vitro. J. Cell Physiol. 184, 33 4 34 0.81. Riancho, J. A., Zarrabeitia, M. T., and Gonzalez-Macias, J. (19 93) Interleukin-4 modulates osteoclast...
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Biochemical, Genetic, and Molecular Interactions in Development - part 7 docx
... 276, 133 65– 133 71.80. Klein-Nulend, J., Burger, E. H., Semeins, C. M., Raisz, L. G., and Pilbeam, C. C. (1997) Pulsating fluid flow stimu-lates prostaglandin release and inducible prostaglandin ... changes in bone modeling and remodeling in response to loading and unloading are initiated byan internal mechanostat that is able to sense strain. In this view, changes in bone remodeling occur in response ... junction-mediated intercellular communication between osteocyte-like MLO-Y4 cells in response to mechanicalstrain. Endocrinology 142, 34 64 34 73. Microgravity and Bone Cells 267because loading induces...
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Biochemical, Genetic, and Molecular Interactions in Development - part 8 pps
... factors in fracture healing. Clin. Orthop. 35 5(Suppl.), S301–S3 13. 164. Rosen, C. J. (1999) Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implica-tions. ... Baylink, D. J. and Linkhart, T. A. (19 93) 1,2 5- Dihydroxyvitamin D3 increases secretion of insulin-like growth factor binding protein-4 (IGFBP-4) by human osteo-blast-like cells in vitro and ... 1.Pax3 and PDGF-_ Receptor 33 5 33 5From: The Skeleton: Biochemical, Genetic, and Molecular Interactions in Development and HomeostasisEdited by: E. J. Massaro and J. M. Rogers © Humana Press Inc.,...
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Biochemical, Genetic, and Molecular Interactions in Development - part 9 potx
... 9.5– 13. 5 dpc by using molecular markers. Aretinoic acid-responsive transcription factor, Ap-2, (42) and cellular retinoic acid-binding protein-1Fig. 5. Analysis of the endogenous levels of retinoic ... Standard developmental toxicity bioassays in rodents include a detailed examination of thenear-term fetal skeleton in single-stained (alizarin red for ossified bone) or double-stained (alizarinred ... mor-phology. Development 121, 33 3 34 6. 30 . Core, N., Bel, S., Gaunt, S. J., Aurrand-Lions, M., Pearce, J., Fisher, A., et al. (1997) Altered cellular proliferation and mesoderm patterning in...
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Biochemical, Genetic, and Molecular Interactions in Development - part 10 doc
... synthesisinduction, 31 1differentiation role, 30 8, 30 9insulin-like growth factor-I, 31 4, 31 5matrix Gla protein, 31 2mineralization stimulation, 30 9, 31 0osteocalcin, 31 1, 31 2osteonectin, 31 3osteopontin, ... 31 3osteopontin, 31 2, 31 3plasminogen, 31 3, 31 4proliferation inhibition, 31 0, 31 1prostaglandins, 31 4table of regulated genes, 31 6transforming growthfactor-`, 31 4Osteocalcin, vitamin D effects ... factorregulation,interferon-a, 2 03, 204interleukin-1, 202interleukin-4, 202interleukin-6, 202, 2 03 interleukin-11, 2 03 macrophage colony-stimulatingfactor, 200, 201osteoprotegerin, 201RANKL,...
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