... inflammatory response in the lungs of mice which is linked to a reduction in HDACactivity and may be a key mechanism of glucocorticoidinsensitivity in COPD [11,17,21]. Both this reduction in HDAC ... maylead to the alteration of both the formation and targeting of these complexes. Consequently, an oxidant-mediatedreduction in the protein expression of Mi-2α and mSin3aand increased protein ... machinery including the corehistone proteins resulting in their in re-association with the DNA, thus presenting a transcriptionally closed con-formation [1,16].HDAC-2 function is impaired by...