... steps in the other. The mdm2 target, whose interaction with p53 was moststrongly affected by DNA cis-platination, containsGG, GGG and AG motifs in one strand and GG and GTG motifs in the other, ... binding to DNA treatment with cisplatin and the ability of the particular p53target site to accommodate the cisplatin IACs. The higher the probability of formation of the cisplatinIACs within ... within the p53DBSs due to the occurrence of the GG, AG and ⁄ or GNG motifs, the stronger the inhibition of the p53 sequence-specific DNA bindingto these targets caused by the DNA treatment with cisplatin.ABFig....