... -10,163Rofecoxib 1.26 2.13 0.64 1,563Any dose of drug was allowed in the data, and the table additionally shows the rate and frequency of additional events. The calculations used a mortality rate of ... from systematic reviews and meta-analyses. Coxib, cyclooxygenase-2 inhibitor; NSAID, non-steroidal anti-inflammatory drug; GI = gastrointestinal; CV = cardiovascular.Table 3Additional gastrointestinal ... rareadverse events are often associated with death. Myocardial inf-arction, gastrointestinal bleeding, and rhabdomyolysis, for exam-ple, can be fatal or non-fatal, and the fatality rate is known....