... 2 analysis of variance (ANOVA). For the first data analysis, treatment and time were the independent factors using all 23 subjects. The second analysis sep-arated and analyzed the data according ... Safety of bitter orange (Citrus au-rantium) and its primary alkaloid p-synephrine. HerbalGram 2011; 89: 34-39. 13. Haller CA, Duan M, Peyton J III, et al. Human pharmacology of a performance-enhancing ... Putzbach K, Nelson BC, et al. Certification of standard reference materials containing bitter orange. Analyt Bioanalyt Chem. 2008; 391: 2023-2034. 23. Stewart A, Fernando R, McDonald S, et al....