Atlas of Clinical Hematology - part 1 ppsx
Atlas of Clinical Hematology potx
... Dr. Witte of Erlangen,Dr. Langreder of Mainz, Prof. Dr. Mohr of the Tropical Institute of Hamburg,Dr. Moeschlin of Zurich, Dr. Undritz of Basel, and Dr. Kuhn of our FreiburgClinic. We also thank ... We also thankthe Institute of Pathology of the University of Kiel, headed by Prof. Karl Len-nert, and the current head of the Department of Hematologic Pathology,Prof. Reza Parwaresch, for preparing ... sections of the tissue coresthat we submitted.AcknowledgementsWe are indebted to Prof. Brigitte Schlegelberger, Prof. Werner Grote (direc-tor of the Institute of Human Genetics, University of Kiel),...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of ... volume of distribution of lidocaine is reduced. Therefore, lower-than-normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... administration of "loading" dosages may result in more rapid elevations of drug concentration to achieve therapeutic effects earlier than with chronic maintenance therapy (Fig. 5 -4). Nevertheless,...
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Chapter 019. Fever of Unknown Origin (Part 1) ppsx
... Causes (%) Chapter 019. Fever of Unknown Origin (Part 1) Harrison's Internal Medicine > Chapter 19. Fever of Unknown Origin Definition and Classification Fever of unknown origin (FUO) ... Beeson in 1961 as (1) temperatures of >38.3°C (>101°F) on several occasions; (2) a duration of fever of >3 weeks; and (3) failure to reach a diagnosis despite 1 week of inpatient investigation. ... the number of undetected cases of systemic lupus erythematosus and other autoimmune diseases. Table 19-1 Classic FUO in Adults Authors (Year of PublicatiYears of Study o. of Cases...
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Fundamentals of Clinical Ophthalmology - part 1 ppsx
... (Figure 8 .13 b, 10 .23, 10 .24, 10 .26, 12 .13 , and 12 .22b), Frank Larkin (Figure 12 .14 ),Graham Lee (Figure 7.3a,b), Ordan Lehmann (Figures 8 .14 , 12 .12 , 12 .15 , 12 .18 , 12 .22a, 12 .24,and 12 .26), Martin ... level of the microscope eyepieces). CONTENTSvi 13 Cataract surgery in the Third World 19 3 14 Cataract surgery: the next frontier 200Index 208 ixPreface to the Fundamentals of Clinical Ophthalmology ... editorSUSAN LIGHTMANDepartment of Clinical Ophthalmology, Institute of Ophthalmology/ Moorfields Eye Hospital,London, UK © BMJ Publishing Group 2003BMJ Books is an imprint of the BMJ Publishing...
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Atlas of Clinical Hematology - part 1 ppsx
... Reaction) 11 1. 11 Sudan Black B Stain 13 1. 12 Cytochemical Determination of Peroxidase 13 1. 13 Hydrolases 13 1. 13 .1 Cytochemical Determination of Leukocyte Alkaline Phosphatase (LAP)in Blood Smears 13 1. 13.2 ... CausativeOrganisms of Tropical Disease 399 IITable 2. Cytochemistry of blood and bone marrow cellsPer-oxidasePAS Esterasea-Naphthyl-acetate-,Naphthol-AS-acetate-Naphthol-AS-D-chloracetate-Phosphatasesalkaline ... formalin (10 : 1) . DAB solution: 5 mg diaminobenzidine tetrahy-drochloride in 20 mL of 0.05 mol/L tris-HClbuffer (pH 7.6) with 50 lLof1%H2O2added Tris-HCl: 50 mL of solution A (12 1 .14 g...
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Atlas of Clinical Hematology - part 2 pot
... pro-ceeding with a more detailed evaluation.Figure 22 f, g shows the appearance of a normalbone marrow smear viewed at high magnifica-tion. Figure 22 a, b illustrates the range of varia-tion ... (histologic sec-tions). Figure 22 c shows how the naphthol AS-Dchloroacetate esterase method can be used to lo-calize early neutrophilic granulocytop oiesis closeto bony trabeculae. Figure 22 d, e ... myeloidleukemiaChronic lympho-cytic leukemiaAgranulocytosis 20 40 60 80 20 40 60 80 20 40 60 80 20 40 60 80 20 40 60 80 20 40 60 80 20 40 60 80 20 40 6080Reticulum cellsPlasma cellsMegaloblastsBasophilicproerythroblastsPolychromaticerythroblastsOrthochromaticnormoblastsMyeloblastsNeutrophilicpromyelocytesNeutrophilicmyelocytesNeutrophilicmetamyelocytesBand...
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Atlas of Clinical Hematology - part 3 pps
... Marrow IVFig. 35 a –d. Effect of hematopoieticgrowth factorsa Peripheral blood smear after the ad-ministration of G-CSFb Left shift following G-CSFc Maximum leukocyte alkaline phos-phatase ... following G-CSFd Bone marrow following chemotherapyand the administration of G-CSF de-monstrates promyelocytes and myelo-cytes, some showing mild atypia1 13 5 · Bone Marrow IVFig. 36 a –h. ... addi-tion, Heinz body formation is characteristic of a number of enzymopenic HA, and methemoglo-bin is increased in toxic HA.Several groups of hemolytic anemias are re-cognized on the basis of...
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Atlas of Clinical Hematology - part 4 potx
... andpaucity of fat cellsd Histologic section during chronicphase of CML. Naphthol AS-D chloro-acetate esterase reaction shows an ex-treme increase in neutrophilic granulo-cytopoiesis 148 Chapter ... BCR-ABL translocation, the demonstra-tion of low or even negative leukocyte alkalinephosphatase (LAP, see p. 13) w as of key impor-tance. Today the diagnosis is established by detec-tion of ... the cytogenetic detec-tion of the (9;22) translocation or the moleculargenetic detection of the BCR-ABL translocation.The absence of these changes preclude s a diagno-sis of CML (CGL).Almost...
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Atlas of Clinical Hematology - part 5 pdf
... ne-cessary for an accurate classification189 5 · Bone Marrow IVFig. 66 i Partial karyotype of a dicentricchromosome 5; 17 that leads to asimultaneous loss of the long arm of chromosome 5 ... the short arm of chromosome 17. The loss of the shortarm of chromosome 17 (17p-) causesthe loss of an allele of p53, which islocalized there in the band 17p13.Structural cha nges of 17p are ... irondeposition in the cytoplasm of a plasmacell in RARS. Nucleus is at lower right.c–f The 5q-minus syndromec Two megakaryocytes with round nu-clei and different stages of cytoplasmicmaturity –...
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Atlas of Clinical Hematology - part 6 doc
... cyto-plasm and, above the nucleus, a signal(blue-green dot at lower right) from thenormal chromosome 16 and a two -part signal (two groups of small dots at left)from the inverted chromosome 16. ... Variants of the M4 sub-typea Severely dysplastic erythropoiesis. Atcenter are three erythroblasts, two of which are very immature forms. The cy-toplasm of the upper erythroblast is va-cuolatedb ... theerythroblasts of the same patient. Thisfinding should not be mistaken for T-cellALLf PAS reaction in the bone marrow of thesame patientg Extremely immature form of M6a.Some of the cells...
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Atlas of Clinical Hematology - part 7 ppt
... subtype of ALL violates the dogma that cytoplas-mic granules are suggestive of AML.This case is a B-lineage type of ALL withcytoplasmic granules that are peroxi-dase-negative and behave as lyso-somesa ... isolated Lan-ghans giant cells Fig. 138 a, b), and toxoplasmosis(epitheloid-cell lymphadenitis of Piringer-Ku-chinka, see Fig. 136 a – d).In the examination of cervical lymph node as-pirates, ... classification of acuteleukemias. European Group for theImmunological Characterization of Leukemias (EGIL). Leukemia. 9: 178 3– 178 6]. These types of leukemia mostcommonly occur in early T-ALL withmyeloid...
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Atlas of Clinical Hematology - part 8 potx
... koăn-nen B- und T-Zell-Lymphome unterschieden wer-den. B-Zell-Lymphome sind in Europa und Ame-rika haăufiger, waăhrend die T-Zell-Lymphome inAsien uăberwiegen. Unter Einbeziehung von mor-phologischen ... Immunphaănotyp oder gene-tisch-molekulargenetisches Profil nicht moăglich.B-, T- und NK-Zell-Neoplasien werden weiterin Vorstufen-(Precursor) und reife (mature) Er-krankungen unterteilt. ... Befunden, Im-munphaănotyp, Zytogenetik und Molekulargene-tik sowie klinischen Daten hat die WHO-Arbeits-gruppe nach den Prinzipien der Revised Euro-pean-American Classification of Lymphoid Neo-plasms...
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Atlas of Clinical Hematology - part 10 pptx
... is sig-nificant lymphadenitis with clinical manifesta-tions such as headache, low-grade fever, and sin-gle or multiple lymph node enlargement, particu-larly in the neck. Involvement of the ... the rest of the patient’s life, sig-nifying that the infection has entered its latentstage. Recently, the so-called test of avidityproved to be of help in calculating the duration of infection ... Important Causative Organisms of Tropical Diseases VIIFig. 195 a – d. Filariasisa Microfilaria of Mansonella perstans, seealso Fig. 196b High-power view of a Loa loa micro-filaria with granules...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx
... Multiple Databases 15 1 A Recipe for Disaster 15 2Transferring Data 15 4Quality Assurance and Security 15 5Maintaining Patient Confidentiality 15 5Access to Files 15 5Maintaining an Audit Trail 15 7Security ... 14 3Hierarchical Databases 14 5Network Database Model 14 6Relational Database Model 14 6Which Database Model? 14 9Object-Oriented Databases 15 0Clients and Servers 15 0One Size Does Not Fit All 15 1Combining ... 18 4Extending the Trials 18 6Budgets and Expenditures 18 6For Further Information 18 7 15 Data Analysis 18 9Report Coverage 18 9Understanding Data 19 0Categories 19 0Metric Data 19 2Statistical...
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