Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons ppsx
Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons ppsx
... RESEA R C H Open Access Parkinson’s disease candidate gene prioritization based on expression profile of midbrain dopaminergic neurons Shahrooz Vahedi1, Mehrnoosh Rajabian1, ... midbrain dopaminergic neurons. Genetic association studies have linked13 human chromosomal loci to Parkinson’s disease. Identification of gene( s), as part of the etiology of Parkinson’s disease, ... identify PD genes.Methods: In this work we have used the combination of findings from six rodent transcriptome analysis studies on the gene expression profile of midbrain dopaminergic neurons and...
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Báo cáo khoa hoc:" Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson''''s disease in two European populations" pps
... role of Parkin gene variations in the late-onset form of PD (age of onset >45years): Parkin mutations appear to contribute to the com-mon late-onset form and mutations, especially in exon ... functional investigations of thePINK1 protein are necessary to identify potential interac-tion partners as candidates for additional mutationscreening.ConclusionInvestigations of other genes ... question arises as towhether the PINK1 gene is also a candidate gene for late-onset forms of Parkinson's disease, similar to the sug-gested role of the Parkin gene. Here we report of a...
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báo cáo hóa học: " The effects of high frequency subthalamic stimulation on balance performance and fear of falling in patients with Parkinson''''s disease" docx
... the effect of STN stimulation alone,comparisons were made between DBS OFF (Deep BrainStimulation turned off) and DBS ON after an overnightwithdrawal of anti-PD medication. The Wilcoxonmatched-pairs ... postural control in Parkinson's disease, whereas medication does not. Mov Disord 2006, 21:1088-1097.47. Magnusson M, Johansson K, Johansson BB: Sensory stimulationpromotes normalization of postural ... stimulation canimprove postural control is under debate [12]. The effect of STN stimulation alone can be studied after overnightwithdrawal of anti-PD medication and by turning thestimulation OFF...
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báo cáo hóa học: "Effect of gait speed on gait rhythmicity in Parkinson''''s disease: variability of stride time and swing time respond differently" docx
... not simply a consequence of bradykinesia.IntroductionFalls are one of the most serious complications of the gaitdisturbance in Parkinson's disease (PD) [1-7]. Beyond theacute trauma that ... patients or con-trols), the walking condition (e.g., treadmill or walker),walking speed, and the interaction term group × walkingcondition × walking speed. P values reported are based on two-sided ... based on comparisons between CWS walking to slower walking in PD and controls.Journal of NeuroEngineering and Rehabilitation 2005, 2:23 http://www.jneuroengrehab.com/content/2/1/23Page 5 of...
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báo cáo hóa học: "Effect of step-synchronized vibration stimulation of soles on gait in Parkinson''''s disease: a pilot study" doc
... clin-ical value of the S-VS.AbbreviationsPD Parkinson's disease S-VS step-synchronized vibration stimulationVD vibratory deviceCV coefficient of variationCoP center of pressureUPDRS ... AccessResearchEffect of step-synchronized vibration stimulation of soles on gait in Parkinson's disease: a pilot studyPeter Novak*1 and Vera Novak2Address: 1Department of Neurology, Boston University ... while on medication that correspond to subscore 1–2 on the Unified Parkinson Disease Rating Scale (UPDRS),Table 1: Demographic and clinical characteristics of subjects with Parkinson's disease PD...
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báo cáo hóa học: " Effect of optical flow versus attentional strategy on gait in Parkinson''''s Disease: a study with a portable optical stimulating device" pptx
... and correspondent p values are reported.ResultsComparison of gait parameters among the baseline condi-tion (BL), the conditions with continuous optic flow(BOF, FOF) and the condition implying ... Parkinson's Disease. Com-parison of gait velocity, stride length and cadence between the baseline condition (BL), the conditions involving optic flow (BOF, FOF) and the condition involving ... removal [2].A second hypothesis concerning the mechanism of motorfacilitation by visual cues, relies on the effects of the opticflow on the peripheral vision produced by the motion of stripes with...
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The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... cells andunder the conditions of the Salmonella/reversion assay, as demonstrated previouslyby some of these workers.A number of genes important for expression of detoxification and antioxidantdefense ... stress;(4) inhibition of cancer cell proliferation and induction of apoptosis; (5) regulation of subcellular signaling pathways and modulation of transcription factors; and (6)inhibition of growth factors ... observations and resulting hypothe-ses into a potential decreased risk of aging, chronic disease, or cancer chemopre-vention and treatment in the general population.11.3 Parkinson’s Disease Parkinson’s...
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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... degradation and71: THE ETIOPATHOGENESIS OF PARKINSON’S DISEASE: BASIC MECHANISMS OF NEURODEGENERATIONconsider that alterations in the a-synuclein gene can inter-fere with the clearance of unwanted ... oligomeri-zation, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson’s disease: implications for pathogenesis and therapy. Proceedings of theNational ... vector-mediated overexpression of humanalpha-synuclein: a new primate model of Parkinson’s disease. Proceedings of the National Academy of Sciences, of the UnitedStates of America, 100 (5),...
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Tài liệu Parkinson’s Disease and Related Disorders docx
... Rotenone model of Parkinsonism – the five years inspection 269Schmidt, W. J., Alam, M.: Controversies on new animal models of Parkinson’s disease Pro and Con: the rotenone model of Parkinson’s disease ... discharge rates of neurons in the basal ganglia output nucleiand in the STN are increased in Parkinson’s disease has been generally confirmed in ani-mal models of Parkinson’s disease, and isalso ... animal model of severe Parkinson’s disease: neonatal6-hydroxydopamine lesion of dopaminergic innervation of striatum 277Mochizuki, H., Yamada, M., Mizuno, Y.: a-Synuclein overexpression model ....
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... LB is a generalhallmark of the PD state, suggesting that the accumula-tion of a-synuclein might cause selective degeneration of dopaminergic neurons [1,4]. Expression of eitherwild-type or mutant ... (fl) expression as a consequence of a-synuclein overexpression; complex, proteins that displayed altered levels as a result of the association of dopamine treatment with a-synuclein overexpression ... University of Verona, Italy3 Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy4 Department of Neuroscience, University of Torino, ItalyIntroduction Parkinson’s disease...
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