Báo cáo y học: "Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance" doc
Báo cáo y học: "Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance" doc
... 1 of 9(page number not for citation purposes)AIDS Research and TherapyOpen AccessResearchStable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 ... harbor and express siRNAgenes with concommittent HIV resistance.ResultsStable gene transfer of CXCR4 and CCR5 shRNAs by SB transposon system To investigate the utility of SB mediated gene transfer ... aim is to evaluate the utility of SB system for stable gene transfer of CCR5 and CXCR4 siRNA genes to derive HIV resistant cells as a first step towardsusing this system for gene therapy.Results:...
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Báo cáo y học: "Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients" pptx
... upregulation is hypothesised to be due to increasedOB biosynthetic activity [18]. The lack of differential gene expression of these anabolic growth factors in our study ismost likely due to the gene expression ... collection of femoral specimens and to the mortuary staff of the Institute of Medical and Veterinary Science for the collection of autopsy specimens. The authors thank Professor David M Findlay (Department ... study suggestssupport of the hypothesis of increased OB biosynthetic activ-ity, as postulated by Dequeker and colleagues [18]. Furtherexperiments using in situ hybridisation and immunohistochemical...
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Báo cáo y học: "A pilot study of rizatriptan and visually-induced motion sickness in migraineu"
... history of mo-tion sickness symptoms with actual or visu-ally-induced motion. Subjects were excluded if they had heart disease, uncontrolled hypertension, a fam-ily history of early myocardial ... subject and technician, with a range of scores for nausea of 0 to 16, for skin color of 0 to 8, for cold sweating of 0 to 8, salivation of 0 to 8, drowsiness of 0 to 8, and head-ache and dizziness ... Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, USA 2. Department of Anesthesiology & Critical Care Medicine, University of Pittsburgh School of Medicine,...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... Med. Sci. 2007, 4 137tory effect of thioglycoside I (phenyl-1’-thio-β-D glucopyranoside) on hSGLT2 and thioglycoside VII (2-hydroxymethyl-phenyl-1’-thio-β-D-galactopyranoside) on hSGLT1. ... the bio-synthesis of chrysomelidial and salicin. These sub-stances are synthesized and secreted as part of a de-fense mechanism used by larvae of beetles (Chry-somelidae). Their synthesis ... adminis-tered orally [27]. Therefore, the aim of the present study was to evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 and hSGLT2 –as a...
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Báo cáo Y học: Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line pptx
... Inc.,New York and London.2. Hosoda, S. & Glick, D. (1965) Biosynthesis of 5-hydro-xytryptophan and 5-hydroxytryptamine from tryptophan by neoplastic mouse mast cells. Biochim. Biophys. Acta. ... mastocytoma P-815 was readily phosphorylated by CaM kinase II. Although the TPH from P-815 cells waseasily phosphorylated by this kinase, its enzymic activitywas not altered by the phosphorylation ... enzyme turnover.Tryptophan hydroxylase (TPH, EC 1.14.16.4), a member of a family of pterin-dependent aromatic amino acid hydroxy-lases [1], catalyzes the conversion of L-tryptophan to 5-hydroxy-L-tryptophan....
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Báo cáo Y học: Beyond the ABCs of CKC and SCC Do centromeres orchestrate sister chromatid cohesion or vice versa? potx
... complement of chromosomes.The fidelity of chromosome transmission is enhanced notonly by the geometry of stable centromere–MT interac-tions, but also by the action of a centromere-basedregulatory system ... [31–34], and by indirectimmunofluorescence and/ or chromatin immunoprecipita-tion, are organized by nucleosomes that are hypo-acetyl-ated and hyper-methylated (i.e. on lysine 9 of histone H3)(Fig. ... Ndc80/Hec1genetically and physically interacts with cohesin. Mitosis-specific centromere proteins such as the mitotic checkpoint protein Mad2 indirectlypromote SCC by inhibiting the activity of APC towards...
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Báo cáo y học: "A comparative study of anxiety and depression in patients with bronchial asthma, chronic obstructive pulmonary disease and tuberculosis in a general hospital of chest diseases" ppsx
... rate of anxiety and depression compared to thegeneral population. A probable cause is the chronicity and severity of pulmonary disease. Detection and manage-ment of these mental disorders may ... inadequacy may lead to heightened anxiety and depression, which in turn may worsen the everyday inad-equacy. It has been reported that this is (probably) a factorthat leads BA and COPD patients to ... Validation of the Beck depression inven-tory. In Proceedings of the 10th Hellenic Congress of Neurology and Psy-chiatry: 1983 Edited by: Varfis G. Thessaloniki, Greece: UniversityStudio Press;...
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Báo cáo y học: "The opposite effects of fluvoxamine and sertraline in the treatment of psychotic major depression: a case report" potx
... atypical features include moodreactivity in addition to two of the following symptoms:overeating, oversleeping, severe fatigue or leaden paraly-sis, and a history of rejection sensitivity. ... use, distribution, and reproduction in any medium, provided the original work is properly cited.Annals of General Psychiatry 2010, 9:23Kishimoto et al. Annals of General Psychiatry 2010, 9:23http://www.annals-general-psychiatry.com/content/9/1/23Page ... 9:23http://www.annals-general-psychiatry.com/content/9/1/23Page 2 of 3done (4 mg) for about 1 year, and her symptoms wererecovered. Then, she was admitted to the clinic due to delusions of persecution,...
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Báo cáo y học: "he combined effect of gender and age on post traumatic stress disorder: do men and women show differences in the lifespan distribution of the disorder" potx
... group of the41 to 45-year-olds is found to top both ranking lists forDitlevsen and Elklit Annals of General Psychiatry 2010, 9:32http://www.annals-general-psychiatry.com/content/9/1/32Page 9 of ... at the age of 41 to 45 years formen (51.81; SD = 21.17) and at the age of 51 to 55 yearsfor women (64.73; SD = 17.32). It was found to be lowestat the age of 21 to 25 and 71 to 75 years for ... Women TotalAge,yearsPTSD,%Age,yearsHTQ total(SD)Age,yearsPTSD,%Age,yearsHTQ total(SD)Age,yearsPTSD,%Age,yearsHTQ total(SD)1 41 to 45 18.2 41 to 45 51.71 (20.84) 51 to 55...
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Báo cáo y học: "Dynamic magnetic resonance of the wrist in psoriatic arthritis reveals imaging patterns similar to those of rheumatoid arthritis" pps
... interpretation of data and to the critical revision of the article for importantintellectual content; ES and GG contributed to the conception and design of the study, to the analysis and interpretation of data, ... thedetermination of the erythrocyte sedimentation rate (Wester-gren method), C-reactive protein, and IgM rheumatoid factor by standard laboratory methods. In addition, a control group of eight healthy volunteers, ... clinical and laboratory indexes of RA inflammation and dynamic MRI. However, the inclusion of severely activearthritis only – with exclusion of patients in remission – and therelatively low mean...
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