Báo cáo y học: "Vive la différence: biogenesis and evolution of microRNAs in plants and animals" ppt
Báo cáo y học: "Vive la différence: biogenesis and evolution of microRNAs in plants and animals" ppt
... loaded in AGO2 require their 2′-O-methylation to remain stable in the presence of highly complementary targets [102]. Reciprocally, instability of Drosophila miRNAs loaded in AGO1 was induced by ... dsRNA, are methylated by HEN1 as single-stranded species [39-42]. In addition to this core machinery, several accessory factors in uence the biogenesis efficiency, fidelity and sorting of animal miRNAs ... heterogeneous small interfering RNAs (siRNAs). As regulatory relationships are rened, the precision and phasing of hairpin processing may increase. Shortening of the hairpin to produce a single dened...
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Báo cáo y học: "Foramen Magnum Arachnoid Cyst Induces Compression of the Spinal Cord and Syringomyelia: Case Report and Literature Review"
... arachnoid cyst; syringomyelia. Introduction The commonest type of arachnoid cyst that causes compression of the spinal cord and develop-ment of syringomyelia is the Chiari malformation type I ... Burkhardt K, Delavellle J, et al. Symptomatic syringomyelia occurring as a late complication of posterior fossa medulloblastoma removal in infancy in a boy also suf-fering from scaphocephaly. Childs ... compression of the spinal cord and development of syringomyelia [11,12]. Common features of these lesions are secondary cer-ebellar tonsillar herniation with syringomyelia due to mass effect, and...
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Báo cáo y học: "Food allergy management from the perspective of patients or caregivers, and allergists: a qualitative study" docx
... anaphylaxis showedthat delayed or no administration of epinephrine was afactor in many of the deaths [2]. Similar trends wereseen in US mortality data recorded by the AmericanAcademy of Allergy, ... allergies in terms of restriction of social activities,increased fear and anxiety, lack of understanding byothers, and feelings of isolation[5]. To improve support of patients, physicians need to ... questionnaire and transcribed physi-cian interviews were analyzed using content analysis of grounded theory methodology [6,7]. In the event of missing data on the questionnaires, all questions and existing...
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Báo cáo y học: "A case study evaluating the use of clozapine in depression with psychotic feature" docx
... Kaladjian A, Azorin JM, Giudicelli S: Clozapine in thetreatment of psychotic refractory depression. Br J Psychiatry1993, 163:822-4.9. Hrdlicka M: Combination of clozapine and maprotiline in refractory ... than standard, sec-ond and third line treatment for psychotic depression, in improving mood and psychotic symptoms', there remainsmuch uncertainty and we would support further research in ... chlorpromazine and olanzap-ine medication were stopped and she was started onhaloperidol and amitriptyline. Two days later, she startedexperiencing second person auditory hallucinations of therapist...
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Báo cáo y học: "Risk factors predict post-traumatic stress disorder differently in men and women" ppt
... important in predicting PTSD in men and women, it may result in dif-ferences in the resulting psychopathology, which in turnAnnals of General Psychiatry 2008, 7:24 http://www.annals-general-psychiatry.com/content/7/1/24Page ... caring for babies to run orfight in the face of danger. Instead, evolutionary adaptivebehaviour has been tending to offspring, calming childrendown and getting them out of harm's way, and ... equally in men and women. In terms of family history of mental disorders, conflicting evidencehas been found, with one study reporting a significantrelationship in men, but not in women, [13] and...
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Báo cáo y học: "IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats" ppt
... activity of inflammatory cytokines in patients with RA inhibits bone resorption and destruction.IL-23, which was recently identified as a heterodimeric, proin-flammatory cytokine and new member of ... onset of clinical arthritis.Staining of synovial tissues with hematoxylin and eosinshowed that treatment with a low dose (3.0 μg) of anti-IL-23antibody markedly reduced inflammatory changes and ... antibody after the onset of CIA inhibited theprogression of X-ray changes including joint space narrowing and bone erosion. A previous report revealed that expression of proinflammatory cytokines including...
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Báo cáo y học: "New data favouring that neurotrophins are of importance in arthritis" pot
... in fibroblast-like synoviocytes, as seen by ELISAanalysis on culture supernatant. The authors concluded thatinfiltrating T lymphocytes and myeloid cells are the mainsources of NGF in the inflamed ... beenconsidered of importance in various types of inflammatoryconditions. In particular, NGF has been detected at highlevels in regions with inflammation. Accordingly, there arehigh levels of NGF in the ... pathogenesis of pain. In accordance with the findings of Barthel and collaborators[1], immunoreactions for NGF and BDNF have been found in the inflammatory infiltrates of the synovial tissue of arthriticmice...
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Báo cáo y học: " Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome" pptx
... for inter-individual variation in recombination [10,23].This interplay between conservation and variability hasbeen difficult to model. One model explaini ng the rapid evolution of recombination ... Importantly, humanPrdm9 protein was predicted to recognize the aforemen-tioned 13-mer motif CCNCCNTNNCCNC in a zinc fin-ger binding array. The f ast evolution of Prdm9 protein and its binding motif ... paradox [27-29]. In particular, it has been pro-posed that the hotspot paradox can be explained by acombination of cis-andtrans-acting elements thatjointly influence hotspot activity [29,30].One...
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Báo cáo y học: "Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer" pdf
... predominantly in the primary tumor genome before initiation of metastasis [9]. In line with this hypothesis is the finding that distinct clonal cell populations in primary pancreatic carcinoma ... validated by PCR and capillary sequencing. Competing interests The authors declare that they have no competing interests Authors’ contributions WK conceived and designed the study and performed ... genomes, yielding important insights into the genes and mechanisms that contribute to cancer development and progression [5, 6]. Systematic sequence analysis of coding regions in primary and metastatic...
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Báo cáo y học: ": Immune reconstitution inflammatory syndrome (IRIS): review of common infectious manifestations and treatment options" potx
... level of suspicion. In addition to signs of retinitis,inflammatory symptoms include vitritis, papillitis, and macular edema, resulting in symptoms of loss of visualacuity and floaters in affected ... tuberculosis (TB) and cryptococcal meningi-tis following initiation of ART [6,7,10,13,16,25-28]. In noninfectious causes of IRIS, autoimmunity to innateantigens plays a likely role in the syndrome. ... of delayed adequateimmunity.Examples of IRIS in response to intact organisms include,but are not limited to, the unmasking of latent cryptococ-cal infection [22] and infection with Mycobacterium...
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