... hormone[38,40]. The changes engineered in the sequence of the peptide, either through the nature of the side chain of the new amino acids or through their non-native conforma-tional features, increase the ... Analysis of the distribution of the electrostatic potential on the surface of the moleculereveals the ampiphilic character of the helix (Fig. 4A).Schematic representation of the charge distribution ... Aib15]CRH, contain upto 84% helical structure. This value is either somewhatlarger than that of the 76–78% regarding the helicity of the native peptide in solution containing 66–100% of TFE[15,40],...