The principles of toxicology environmental and industrial applications 2nd edition phần 5 ppsx
The principles of toxicology environmental and industrial applications 2nd edition phần 5 ppsx
... attached microtubules to the very center of the cell, lining up in the equatorial plane of the mitotic spindle. With still further growth of the spindle, the chromatids in each pair of chromosomes are ... the cell and are deleted by various repair mechanisms. Some,however, remain undetected and are passed to daughter cells. The significance of the mutations varieswith the type of cell, and the ... 70,000 synthetic240 MUTAGENESIS AND GENETIC TOXICOLOGY Figure 12 .5 Example of DNA adduct formation with benzo-a-pyrene.248TABLE 13 .5 Selected Protooncogenes and the Functions of Their Encoded...
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The principles of toxicology environmental and industrial applications 2nd edition phần 4 ppsx
... oviductal and uterine motility and immobilization of the cilia lining the oviduct. The pertinence of these observations to human exposures and the observed effects of smoking are not clear.However, the ... mucosal barriers, and the unique activity of 189 Principles of Toxicology: Environmental and Industrial Applications, Second Edition , Edited by Phillip L. Williams, Robert C. James, and Stephen M. ... the lung, and these factors alert the phagocytic cells to the location of the agents. The macrophages then engulf them and attempt to ingest them withproteolytic enzymes. An example of a macrophage...
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The principles of toxicology environmental and industrial applications 2nd edition phần 1 ppt
... 1.3 THE IMPORTANCE OF DOSE AND THE DOSE–RESPONSE RELATIONSHIP 9where MW is the molecular weight of the chemical (g/mol) and 24 .5 is the amount (liters) of vaporper mole of contaminant at 25 ... References and Suggested Reading 155 8 Dermal and Ocular Toxicology: Toxic Effects of the Skin and Eyes 157 William R. Salminen and Stephen M. Roberts8.1 Skin Histology 157 8.2 Functions 158 8.3 ... 1General Principles of Toxicology GENERAL PRINCIPLES OF TOXICOLOGY ROBERT C. JAMES, STEPHEN M. ROBERTS, and PHILLIP L. WILLIAMS The intent of this chapter is to provide a concise description of the...
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The principles of toxicology environmental and industrial applications 2nd edition phần 2 ppt
... 120 2 25 2 65 85 Phenobarbital (anticonvulsant) 80 × 4 2 65 130 127 455 155 50 Dexamethasone (glucocorticoid) 100 × 3 2 45 70 80 155 1 25 603-Methylcholanthrened20 × 4 2 15 1 85 300 155 1 45 90PCBs ... × 4 1 75 170 1 95 260 2 15 100 5, 6-Naphthoflavone [BNF] 80 × 3 1 65 4 95 250 130 1 85 85 Benzo(a)pyrened20 × 4 — 1 65 1 65 110 — —Miconazole (antifungal) 150 × 3 150 1 65 140 95 155 100Phenytoin ... 350 × 3100 958 5 959 51203,4 Benzoquinoline 75 × 3 90 230 240 320 140 80Butylated hydroxyanisole(antioxidant)d 50 0 × 10 85 150 1 45 1 45 155 902,2′-Dipyridyl 75 × 3 85 310 2 05 2 35 145...
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The principles of toxicology environmental and industrial applications 2nd edition phần 3 pps
... filtration and tubular secretion are dependent on the concentration of the drugin the plasma, and the rate of reabsorption by the tubules is dependent on the concentration of drug in the urine. The ... enhance the hydration of the skin and increase the rate of uptake of agents applied to the surface of the skin. Forcompounds with the same hydrophobicity, the smaller compound will diffuse across the ... RESPONSES OF THE KIDNEY8Dermal and Ocular Toxicology: ToxicEffects of the Skin and EyesDERMAL AND OCULAR TOXICOLOGY WILLIAM F. SALMINEN and STEPHEN M. ROBERTS The skin is the body’s first line of...
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The principles of toxicology environmental and industrial applications 2nd edition phần 6 pps
... discussed the fundamental concepts of metal toxicity. Because of the largenumber of metals, their ubiquitous nature, and their chemical and physical diversity, the field of metal toxicology is one of ... shortening of the latency (time to tumor) or the number of tumorsat an early age are used, rather than the final tumor incidence measured at the end of the animals’ lives. The use of positive ... lymphoma and from melanoma are also increasing. These data were confirmedin the 1999 joint release from the CDC, NCI, and ACS.As awareness of environmental contamination and the ubiquity of synthetic...
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The principles of toxicology environmental and industrial applications 2nd edition phần 7 pptx
... 74-87-3 CH3Cl 50 .5 –144 –12 3,800 15, 200 2. 15 NDa Methylene chloride 75- 09-2 CH2Cl262 .5 –139 104 350 13,000 ND 1.33 Trichloroethene 79-01-6 C2HCl3131.4 –99 189 58 1,100 4 .53 1 .5 Vinyl ... effective anesthetics, and thisproperty increases with the molecular size. The utility of this property is, however, limited by the irritanteffects of ethers, and the fact that they are easily ... 91-20-3 10 15 A4 10 NE CNitrobenzene 98- 95- 3 1 NE A3 1 NE DNitromethane 75- 52 -5 20 NE NEc100 NE NDPhenol 108- 95- 2 5 NE A4 5 NE DPyridine 110-86-1 5 NE NE 5 NE NDStyrene 100-42 -5 20 40 A4...
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The principles of toxicology environmental and industrial applications 2nd edition phần 8 pot
... justified by the data, and are they consistentwith the current scientific understanding of the test or area of toxicology? •Is the outcome of the reported experiment dependent on the test conditions, ... addition, that is, if they lie above and to the right of the dose-addition line, a synergistic effect can be inferred. On the other hand, responses below the line and to the left indicate antagonism.From ... sound, certain other characteristics of the experimental animals can influencetoxic responses, and therefore the extrapolation of these responses to humans. Examples include the age of the animal...
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The principles of toxicology environmental and industrial applications 2nd edition phần 9 pdf
... concerned. The determination of fitness for a given job should be based on the assessment of the health of the worker and on a good knowledge of the job demands and the worksite. The workers ... implement the full measures and intent of the program, it will not work. The worker is the focus of the entire program and is also involved in the process. Employees areobligated to themselves and their ... information on the chemicals they use including the effects, how they enter the body, and the types of protective equipment they should wear 53 0 CONTROLLING OCCUPATIONAL AND ENVIRONMENTAL HEALTH...
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The principles of toxicology environmental and industrial applications 2nd edition phần 10 pptx
... classification of, 5 13 -5 14 occupational and environmental health: advantages and disadvantages, 5 13 -5 14 bias in, 5 19 -52 0 causation issues, 5 12 -5 13 disease and human health effects, 5 15- 5 16 ... involving the interaction between the nervous system and the hormones of the endocrine glands.neurofibril One of the delicate threads running in every direction through the cytoplasm of the body of ... development, and sexual maturation; and effects on the motherconcern lactation and acceptance of the offspring.resorption The loss of substance in the mucous lining of the uterus.reticuloendothelial...
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