Báo cáo y học: "Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis" ppt
Báo cáo y học: "Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis" ppt
... articleCombined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritisEgidija Sakiniene and L Vincent CollinsDepartment of Rheumatology, University ... α-phenyl-N-tert-butyl nitrone (PBN) was originally developed as ameans of trapping and detecting free radical intermediates[7]. PBN and related nitrones have a variety of anti-inflam-matory and ... early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destructioncommonly results from the unregulated host inflammatory responses to infection. The spin trap compound...
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Báo cáo y học: "Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureu" pot
... administra-tion of different concentrations of IQ-143 on not onlyPrimary metabolismTCA cycle&oxidative phosphorylation&pentose phosphate pathwayGlycolysisAmino acid metabolism:all ... amino acidsFatty acid metabolism:beta oxidation, lipid synthesisPurine metabolismPyrimidine metabolismIntermediary metabolismRedox protectionSalvage pathwaySecondary metabolismFigure ... ]. We con-sidered all pathways of pri mary metabolism: amino acid,carbohydrate, lipid, and nucleotide synthesis and degrada-tion, salvage pathways and energy metabolism (Figure 4).ser_0.00μM...
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Báo cáo Y học: Purification and biochemical characterization of some of the properties of recombinant human kynureninase pptx
... spec-trofluorimetrically at 37 °C, with excitation of the product3-hydroxyanthranilate at 330 nm and emission at 410 nm and 310 nm and 417 nm respectively for anthranilate, bythe method of Shetty & Gaertner ... Inhibition of kynureninase activity byL-kynurenine as a functionof 3-hydroxykynurenine concentration. Data obtained at 10 lMTris/HCl at pH 7.9, 37 °Cand15lMsubstrate concentration (d). Thedepicted ... inflammatory response to injury [2,3].Kynureninase is one of the enzymes involved in thetryptophan metabolic pathway. It is a pyridoxal 5¢-phos-phate (PLP)-dependent enzyme which catalyses the...
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Báo cáo y học: "Incomplete oedipism and chronic suicidality in psychotic depression with paranoid delusions related to eyes" pptx
... experienced great anxiety.He grew up in a very disturbed family. His sister had a seri-ous obsessive-compulsive disorder. His elderly parentslacked empathy and showed hysterical and obsessivebehaviors. ... guilty. This severe guilt ledhim to the eye injury. Contrary to expectations, the eyeself-injury in our patient was not related to any religiousPublish with BioMed Central and every scientist ... taking.Another feature of his personality was somatic anxiety.His disorder distressed him in two totally different areas.On one hand, he felt excited by his desires and thoughts;on the other one hand he...
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Báo cáo y học: "Dietary Use and Conservation Concern of Edible Wetland Plants at Indo-Burma Hotspot: A Case Study from Northeast India" doc
... sprain.Polygonum barbatum Yelang Fresh shoot Paste is taken to treat stomach disorder and dysentery.Polygonum chinense Angom-yensil Plant Paste is given in cut and injuries, fever and dyspepsia.Polygonum ... physically counted and converted into weightbasis, which later on pooled on vendor basis and finallyestimated on market basis. Variations in quantity and prices for each species were also gathered ... ranking and conservation concernsThe community perception on species use and taste,availability in natural habitats and conservation statuswas gathered for various edible wetland plants usingrandom...
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Báo cáo y học: "A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritis" pptx
... nucleotide polymor-phism, haplotyping and linkage disequilibrium, and microsatellites generate a significant amount of correlativedata that requires annotating using various bioinformaticplatforms. ... 78Arthritis Research & Therapy Vol 5 No 2 AminThe key to bioinformatics is integration, interpretabilitybetween various data platforms and the ability to visualizeretrieved complex data in ... difficulty of isolating thephenotype of one gene amid the noise of other genetic and environmental influences. It may be recognized thatthe complexity is hidden in idealized laboratory settingsand...
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Báo cáo y học: "Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis" pptx
... counteracted byAMD3100. Our observations indicate that CXCL12 acts as apro-inflammatory factor in the pathogenesis of autoimmunearthritis by attracting inflammatory cells to joints and bystimulating ... family, CXCL12 may play a role in inflammatory dis-eases. Specifically, there is increasing evidence that CXCL12plays a crucial role in patients with rheumatoid arthritis (RA). InRA patients, ... in wild-type mice and analysed the underlying mechanism. Parenteral treatment withthe drug at the time of onset of arthritis reduced diseaseincidence and modestly inhibited severity in affected...
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Báo cáo y học: "Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis" pptx
... dilatation of 20 patients with early RA and matched controls, and of 31 patients with early RA at baseline and one yearBrachial dilatation of 20 patients with early RA and matched controls, and ... flow-medi-ated dilatation; GMD = GTN-mediated dilatation; GTN = glyceryl trini-trate; RA = rheumatoid arthritis.Table 2Univariate analysis of the relationship between change in flow-mediated dilatation ... cardiovascular; DMARDs: disease-modifying anti-rheumatic drugs; ESR: eryth-rocyte sedimentation rate; FMD: flow mediated dilatation; GMD: GTN-mediated dilatation; GTN: glyceryl trinitrate; HAQ: health...
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Báo cáo Y học: Concerted regulation of free arachidonic acid and hormone-induced steroid synthesis by acyl-CoA thioesterases and acyl-CoA synthetases in adrenal cells pdf
... protein in both adrenal tissue and Y1 adrenal tumor cells by immunohistochemistry and immunocytochemistry and Western blot. Stimulation of Y1 cells with ACTH significantly stimulated endogenousmitochondrial ... shown that dexamethasoneinhibits cholesterol metabolism and that this effect is reverted by free AA, we can not rule out the possibilitythat the free AA that is esterified into acyl-CoA may comefrom ... steroid synthesis in Y1 cells supports this hypothesis. The participation of theAA-CoA-mediated pathway for AA release in steroidogen-esis was further demonstrated by the combined inhibitoryeffect...
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Báo cáo y học: "Combined ablation of atrial fibrillation and minimally invasive mitral valve surgery: a case report" docx
... Preoperativ ely, the present patient hadchronic atrial fibrillation, and the other two had parox-ysmal atrial fibrillation and mitral regurgitation withoutatrial septal defect. They maintained ... using a T-shaped cryoprobewith a lesion set of pulmonary vein isolation and ablation of the left and right isthmus in performing mitral annu-loplasty, tricuspid annuloplasty, and atrial septal defect ... pulmonary veinisolation and ablation of the left and right isthmus inperforming minimally invasive mitral valve surgery. Wedescribe our technique for a creation of a lesion set forablation of atrial...
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