Báo cáo y học: "Measuring effectiveness of drugs in observational databanks: promises and perils" pdf
Báo cáo y học: "Measuring effectiveness of drugs in observational databanks: promises and perils" pdf
... Food and Drug Administration of the USA has intro-duced a requirement for post-marketing surveillance of newer drugs including biological agents; these are nowbeing pursued by pharmaceutical industry, ... bias in assignment of treatment by aphysician. ‘Confounding by indication’ means that certaintreatments are preferentially given to sicker patients and certain treatments preferentially to ... in improvingthe use of databanks. Many of the problems with observa-tional studies can be minimized with careful planning in advance of the study. Ideally the subjects in longitudinaldatabanks...
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Báo cáo y học: "Functional characterization of Trip10 in cancer cell growth and survival" ppsx
... study, Trip10 was only sporadically in the cytosol and perinuclear region of IMR-32 controlcells, but was more evenly distributed in the cytosol of CP70 control cells (Figure 3 immunostaining). ... undetectable in MSCs, slightly methy-lated in CP70, moderately methylated in MCF7, MDA-MB-231 and HepG2 cells, but hypermethylated in IMR-32 and U87 cells (Figure 1A right). In our previousstudy, expression ... MJ, Jin VX, Sun WS, Hung YC, Yeh KT,Yan PS, Lai YY, Sun HS, Lu YJ, Chang YS, Tsai SJ, Huang TH, Leu YW: DNAmethylation of the Trip10 promoter accelerates mesenchymal stem celllineage determination....
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Báo cáo y học: "The epidemiology of intensive care unit-acquired hyponatraemia and hypernatraemia in medical-surgical intensive care unit"
... baselinecreatinine, mechanical ventilation and level of care were asso-ciated with ICU-acquired hypernatraemia.Outcomes of careLength of stay and mortality in the ICU and hospital wereincreased ... patients and hypernatraemia in 2157(26%) patients with an incidence density of 3.1 and 7.4 per 100days of ICU admission, respectively, during 29,142 ICUadmission days. The incidence of both ... data, interpreted data and revised themanuscript. HTS and FK had full access to all the study data and assume responsibility for the integrity of the data and theaccuracy of the analysis.References1....
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Báo cáo y học: "The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient
... ‘mucin-like amino acids, serine, threonine and proline. Serine and threonine are points of O-glycosylation found in the tandem repeat regions of mucins and their ratios can vary with the site of secretion ... solid and cystic areas. The cysts were lined by variable mucosae, including colonic type (Fig. 1a) and respiratory type mucosae (Fig. 1b). Deep to the cyst epithelial lining was a layer of smooth ... made in a study on colorectal carcinoma [34]. The tissue showed mucin of predominantly the acidic type, the sulphated type dominating in the res-piratory epithelium. Acidic mucins especially...
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Báo cáo y học: " Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphis"
... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely-sium Pty Ltd, ... individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients with AML and 13,7% in healthy individuals. After ... pathogenesis of AML. During sequence analysis of exon 10 in the AML samples we identified a new intronic SNP which we subsequently confirmed by sequencing DNA samples of 51 healthy individuals. Interestingly,...
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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral therapy in this high-risk ... Duration of therapy was intended to be 24 weeks in genotypes 2 and 3 and 48 weeks in genotype 1 infection. Hematologic inclusion criteria included ANC > 800 cells/mL, hemoglobin > 10 g/dL and...
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Tài liệu Báo cáo Y học: Temperature dependence of thermodynamic properties for DNA/DNA and RNA/DNA duplex formation pdf
... mds,andmssare the intercepts and slopes of the lower and upper baselines of the melting curves,respectively; T is the temperature of interest in Kelvin, a isthe molar fraction of strands in ... thermodynamic analysisThe differences in hydration between the structured duplexstrand and the coiled single strands gives rise to an increase in the heat capacity [27,49–52], resulting in a ... Enthalpy and heat capacity changes for formation of anoligomeric DNA duplex: interpretation in terms of coupled pro-cesses of formation and association of single-stranded helices.Biochemistry 38,...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... of the human and mouse PXR ligand binding domains.By modeling the human PXR ligand binding domain wehave identified and mutated two polar residues in the puta-tive ligand binding pocket which ... change than thespatially and electrostatically moderate change of a histidineto a glutamine and thereby give additional information intoits potential role in ligand binding. We also made the ... molecularmechanism of ligand binding and activation of PXR bymodeling and site-directed mutation of the PXR ligandbinding domain (LBD). In particular, we wanted to identifyresidues responsible for...
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Báo cáo Y học: The folding of dimeric cytoplasmic malate dehydrogenase Equilibrium and kinetic studies doc
... Bhattacharyya2 and Chanchal Das Gupta11Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata, India;2Indian Institute of ChemicalBiology, Kolkata, IndiaPorcine ... spectradepicting its intermediate feature.Binding of hydrophobic probeThe large loss of fluorescence intensity and little change in the far-UV CD signal are often seen in the transitions of native ... Major change, 75% of total drop of h222ANS binding 0.5–0.9 Increases, indication of intermediate species around 0.75M0.9–1.25 Most potent binding of ANS1.25–6 DecreasesHydrodynamic volume 0.5–0.75...
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Báo cáo Y học: The role of zinc in the methylation of the coenzyme M thiol group in methanol:coenzyme M methyltransferase from Methanosarcina barkeri New insights from X-ray absorption spectroscopy doc
... indicatingthat, in the absence of coenzyme M, zinc is probablycoordinated by a single sulfur ligand and three oxygen ornitrogen ligands. In the presence of coenzyme M, one(N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In theHis237 fi Ala and Cys239 fi Ala mutants, coenzyme Malso seemed to bind efficiently by ligation to zinc indicatingthat some aspects of the zinc ligand ... ligands and in MetEto 2 S and 2 (N/O) ligands [14]. In protein farnesyltransferase the active site zinc is coordinated by 1 S and 3(N/O) ligands, as revealed by the crystal structure [19]. Zincthus...
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