... SMART trial.MelatoninMelatonin is a naturally occurring hormone producedby the pineal gland and is structurally related to seroto-nin. Physiologically, melatonin secretion increases soonBaandrup ... disorder, dementia, epilepsy, terminal illness, severe co morbidity, inability to understandDanish, allergy to melatonin, lactose, starch, gelatin, or talc, hepatic impairment, pregnancy or ... level dur-ing the night is maintained by continuous secretion.Circadin®is prolonged-release melatonin and is approvedas a drug in Europe for primary insomnia in patients aged55 years or above....