... were inhibited by pretreat-ment with rapamycin. LPS-induced iNOS proteinexpression (4 h of incubation, Fig. 3B) and nitrite pro-duction (24 h of incubation, Fig. 3C) were also inhib-ited in ... expressions of iNOS and G-CSF at thetranscriptional level in LPS-treated macrophages. In this study, the effects of rapamycin on the LPS-induced increase in Oct-2 protein and on the expres-sion of ... expression is controlled by the activation of various protein kinases, such as protein kinase A, pro-tein kinase C, Src-related kinases, mitogen-activatedprotein kinases and phosphoinositide 3-kinase...