ANEUPLOIDY IN HEALTH AND DISEASE docx
ANEUPLOIDY IN HEALTH AND DISEASE docx
... missegregation levels both in vitro and in vivo and thus to aneuploidy. Besides mutations in spindle assembly checkpoint and in mitotic spindle genes, aneuploidy is also increased in cells that carry ... are34 Aneuploidy in Health and Disease Aneuploidy in Health and Disease 12specific effect except for AICAR, chloroquine and 17-AAG [50]. AICAR induces energy stress, leading to the activation ... regions within the genome. Number24 Aneuploidy in Health and Disease The Causes and Consequences of Aneuploidy in Eukaryotic Cells 7 mammalian cells and spindle pole bodies in yeast) that...
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Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc
... Cancer Genomics by Jointly Analysing Aneuploidy and Gene Expression 23 Lingling Zheng and Joseph Lucas Chapter 3 Sister Chromatid Cohesion and Aneuploidy 41 Erwan Watrin and Claude Prigent ... Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Aneuploidy in Health and Disease, Edited by ... aneuploidy (Fig. 1). Frequently, a combination of both structural and numerical chromosomal changes can be found, in particular in cancer cells (composite aneuploidy) . Aneuploidy and its link...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinasedomain. The mutated residues are indicated in yellow, a-helices are in cyan, ... T-cell kinase (ITK) could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining ... Holland J, DaviesA, Flinter F, Hammarstrom L, Kinnon C, LevinskyR, Bobrow M et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the srcfamily of protein-tyrosine kinases....
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Modern Nutrition in Health and Disease pot
... myofibrillar protein from tissues containing myosin and actin (muscle, smooth muscle such as gut, skin). In man, 3-methylhistidine is quantitatively excreted into urine; in rat, 3-methylhistidine is also ... of Free Amino Acids in the BodyIt is important to bear in mind the differences in the relative amounts of N contained in extracellular and intracellular amino acid pools and in protein itself. ... to measure arginine kinetics in pediatric burn patients and determined little net de novo arginine synthesis, suggesting that under conditions of burn injury, insufficient arginine is made to...
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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf
... integrin-binding ligandN-linked glycoprotein (SIBLING)Individual members of the SIBLING family are knownto bind strongly to both pro- and active forms ofspecific MMPs. Bone sialoprotein binds ... proMMP-binding partnersinvolved in activation.Allosteric activationGelatinase interactions with collagen and gelatinBinding of macromolecules or specific thiol-bindingreagents to an MMP with an intact ... activation by binding tothe 64 kDa intermediate form of MMP-2 [52]. Binding and activation of MMP-2 was abrogated in the pres-ence of avb3 integrin-binding macromolecules such asvitronectin and HKa...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot
... and mRNA binding to cytosolic and poly-some proteins in brain and peripheral tissues. Brain Res. Mol. Brain Res. 58, 170–177.39. Lauger, P. (1991) Na,K-ATPase, in Electrogenic Ion Pumps, Sinauer, ... HOMEOSTASIS AND NEUROLOGICAL DISEASE Substantial progress has been made in the understanding of the pathophysiology and mechanisms involved in the attenuation of brain homeostasis. In many diseases ... metabolites and to remove waste products.The Neuronal Environment: Brain Homeostasis in Health and Disease examines the function of all the components involved, including their perturbation dur-ing...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
... modulated by lumican-evoked signaling,including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe-sion ... with the EGF-binding domain [32]. Thestructural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... leucine-rich proteoglycans (SLRPs) are involved in many aspectsof mammalian biology, both in health and disease. They are now being rec-ognized as key signaling molecules with an expanding...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... HEXXHXXGXXH) and a conserved methionine(Met-turn) supporting the catalytic zinc. Interactionbetween cysteine–zinc maintains proMMPs in an inac-tive state by preventing a water molecule from bindingto ... (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a class II PSD-95 ⁄Discs-large ⁄ Zonula occludens protein-binding motifFXF, ... (Pro) containing a cysteine switch motifPRCGXPD (except for MMP23 which lacks thecysteine switch motif) that maintains them as inactivezymogens, and a catalytic domain with a z inc-binding site(Zn,...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... Accumulating evidences indicate thatHSPGs act to inhibit cellular invasion by promotingtight cell–cell and cell–ECM interactions, and by main-taining the structural integrity and self-assembly ... in lungcarcinoma and chronic myeloid leukemia comparedwith control tissue and cells. In this splice variant,144 bp of intron 5 are joined with exon 4, resulting in a 169-amino-acids protein ... theseemingly distinct protein domains observed in the 3Dmodel, namely the TIM-barrel and C-domain regions,mediate enzymatic and nonenzymatic functions of hep-aranase, respectively. Interestingly,...
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