... various levels of theERK1 /2 cascade as well as testing the effects of these agentson other signaling circuitries that may crosstalk to ERK1 /2. ERK1 /2 as a transducer of extrinsic survivalsignalsThe ... bcl -2 and bag -1 . For instance, the prosurvival activity of ERK1 /2 in PC 12 cells may proceed via CREB-stimulated expression of bcl -2 [40]. Furthermore, in HSV2-infected neurons, apoptosis wassuppressed ... FEBS Lett. 5 02, 21 24 .7. Borsch-Haubold, A.G., Pasquet, S. & Watson, S. P. (19 98) Directinhibition of cyclooxygenase -1 and -2 by the kinase inhibitors SB 20 3580 and PD 98059. SB 20 3580 also...