... β1.A number of proteinase families are capable of generating the proteolytic fragments of versi‐can. Matrix metalloproteinase (MMP )-1 , -2 , -3 , -7 , and -9 , ADAMTS-1, -4 , -5 and -9 cleaveversican ... provided the original work is properly cited.high grade gliomas. The structure and compounds of the ECM of the brain tissue havemany specific differences from other human organs. The ECM of the brain ... from the tumor-ECM. Beside the increasedamount of VEGF, the receptors VEGF-R1, VEGF-R2 and VEGF-R3 are upregulated on endo‐thelial cells in glioma in comparison to normal brain. [17 5- 182]Other...